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Brain Tumors: From Biomarkers to Novel Therapies

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".

Deadline for manuscript submissions: 31 August 2024 | Viewed by 639

Special Issue Editor


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Guest Editor
Division of Hematology and Oncology, Department of Pediatrics, Medical School, University of Minnesota, Twin Cities, Minneapolis, MN 55455, USA
Interests: brain tumors; clinical biomarker; drug discovery

Special Issue Information

Dear Colleagues,

We cordially invite you to submit manuscripts for our upcoming Special Issue dedicated to brain tumors. This issue is designed to encompass a broad spectrum of translational studies, ranging from circulating biomarkers to the intricate molecular pathogenesis of brain tumors. Our primary objective is to curate a collection of manuscripts that delve into the molecular intricacies controlling the development and progression of tumors in both pediatric and adult brain malignancies.

We specifically encourage submissions that bridge the gap between fundamental molecular research and its practical clinical applications. Manuscripts elucidating molecular pathways and factors governing tumor development are highly sought after. Furthermore, we invite contributions that transcend theoretical knowledge and translate it into tangible clinical advancements. This includes innovative therapeutic drugs, cutting-edge extracellular vesicles (EV)-based gene delivery tools, and groundbreaking screening tools utilizing patient serum/EVs as biomarkers for brain tumors.

By disseminating groundbreaking research, we aim to foster collaboration and understanding in the complex landscape of brain tumors. We believe that this Special Issue will contribute significantly to our scientific knowledge and pave the way for novel and effective interventions, ultimately leading to improved outcomes for patients grappling with these challenging conditions.

We look forward to receiving your insightful contributions to this Special Issue, which promises to be a cornerstone in advancing our understanding and treatment of brain tumors.

Dr. Okay Saydam
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • glioblastoma
  • medulloblastoma
  • meningioma
  • brain tumors
  • exosomes
  • circulating tumor markers
  • drug development and delivery technologies
  • molecular biology

Published Papers (1 paper)

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Research

22 pages, 2693 KiB  
Article
The OTX2 Gene Induces Tumor Growth and Triggers Leptomeningeal Metastasis by Regulating the mTORC2 Signaling Pathway in Group 3 Medulloblastomas
by Elisabet Ampudia-Mesias, Charles S. Cameron, Eunjae Yoo, Marcus Kelly, Sarah M. Anderson, Riley Manning, Juan E. Abrahante Lloréns, Christopher L. Moertel, Hyungshin Yim, David J. Odde, Nurten Saydam and Okay Saydam
Int. J. Mol. Sci. 2024, 25(8), 4416; https://doi.org/10.3390/ijms25084416 - 17 Apr 2024
Viewed by 438
Abstract
Medulloblastoma (MB) encompasses diverse subgroups, and leptomeningeal disease/metastasis (LMD) plays a substantial role in associated fatalities. Despite extensive exploration of canonical genes in MB, the molecular mechanisms underlying LMD and the involvement of the orthodenticle homeobox 2 (OTX2) gene, a key driver in [...] Read more.
Medulloblastoma (MB) encompasses diverse subgroups, and leptomeningeal disease/metastasis (LMD) plays a substantial role in associated fatalities. Despite extensive exploration of canonical genes in MB, the molecular mechanisms underlying LMD and the involvement of the orthodenticle homeobox 2 (OTX2) gene, a key driver in aggressive MB Group 3, remain insufficiently understood. Recognizing OTX2’s pivotal role, we investigated its potential as a catalyst for aggressive cellular behaviors, including migration, invasion, and metastasis. OTX2 overexpression heightened cell growth, motility, and polarization in Group 3 MB cells. Orthotopic implantation of OTX2-overexpressing cells in mice led to reduced median survival, accompanied by the development of spinal cord and brain metastases. Mechanistically, OTX2 acted as a transcriptional activator of the Mechanistic Target of Rapamycin (mTOR) gene’s promoter and the mTORC2 signaling pathway, correlating with upregulated downstream genes that orchestrate cell motility and migration. Knockdown of mTOR mRNA mitigated OTX2-mediated enhancements in cell motility and polarization. Analysis of human MB tumor samples (N = 952) revealed a positive correlation between OTX2 and mTOR mRNA expression, emphasizing the clinical significance of OTX2’s role in the mTORC2 pathway. Our results reveal that OTX2 governs the mTORC2 signaling pathway, instigating LMD in Group 3 MBs and offering insights into potential therapeutic avenues through mTORC2 inhibition. Full article
(This article belongs to the Special Issue Brain Tumors: From Biomarkers to Novel Therapies)
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