Molecular Mechanisms and Treatments of Organ Hypoxia or Ischemia
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 15 May 2024 | Viewed by 1502
Special Issue Editors
2. Institute for Stroke and Dementia Research (ISD), University of Munich Medical Center, 81377 Munich, Germany
Interests: tissue hypoxia; stroke; neuroimmunology; tissue plasticity; neuroregeneration; sepsis
Interests: pharmacology; cardiac remodeling; cardiac regeneration; sepsis; heart failure; hypertension; atherogenesis
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Hypoxia in organs is a result of ischemia, due to either macrovascular or microvascular circulation collapse. It is a process that occurs either abruptly and acutely or gradually and chronically. Ischemia and hypoxia occur in brain stroke, traumatic brain injury, vasospasmus after subarachnoid hemorrhage, myocardial infarction, kidneys, and the gastrointestinal system; secondary hypoxia occurs during autoimmune inflammation or sepsis. This means that tissue hypoxia is a cardinal underlying process in almost every pathology.
However, hypoxia-induced pathologies lack up-to-date effective treatments. This is the well-known “translational block of protection” in the brain, heart, and other organs, which persists despite decades of research.
In our Special Issue (SI), we want to stimulate an “out-of-box” scientific interchange of studies that test conceptually novel molecular mechanisms and approaches for the detection and treatment of tissue hypoxia. We welcome the interdisciplinary crossing of scientific borders, e.g., by examining how a molecular pathway may be comparatively similar or different in a hypoxic brain, heart, kidney, or inflamed organ and why. Among others, we aim to collect papers with well-supported, “high-risk, high-innovative” ideas in the field of tissue hypoxia.
Dr. Athanasios Lourbopoulos
Prof. Dr. Iordanis Mourouzis
Guest Editors
Manuscript Submission Information
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Keywords
- stroke
- myocardial infarction
- organ hypoxia
- hypoxic molecular mechanisms
- secondary hypoxia
- inflammatory hypoxia
- translational studies
- diagnostic
- treatment
