Muscle Atrophy: From Bench to Bedside 2.0
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 31 August 2024 | Viewed by 1016
Special Issue Editor
Interests: skeletal muscle atrophy; ubiquitin proteasome system; E3 ligases; E2 ubiquitin conjugating enzymes
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The loss of muscle mass is a common adaptation to some physiological situations (e.g., bed rest), but also to many diseases (e.g., diabetes, cancer, heart failure, respiratory failure, renal failure, and sepsis), and is caused by an imbalance of both protein synthesis and protein degradation. Muscle loss contributes to frailty syndrome and is associated with an impaired quality of life and an increased risk of death, regardless of the causal disease. In addition, muscle loss also decreases the efficiency of treatments, such as chemotherapy in cancer patients. Fighting against muscle loss is thus a major goal for ameliorating patients’ health. Compelling data have demonstrated that increased proteolysis is often the primary factor leading to muscle wasting. However, muscle atrophy is a highly coordinated process that implies the concomitant regulation of anabolic and catabolic pathways, which suggests that studies ought not to be restricted to to proteolysis. Therefore, a potential strategy to improve patients’ condition is to minimize muscle wasting by regulating either proteolysis, protein synthesis or both.
This Special Issue will gather recent insights into the mechanisms driving muscle atrophy, welcoming both original and review articles.
Dr. Daniel Taillandier
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- muscle atrophy
- human diseases
- proteolysis
- protein synthesis
- proteolytic systems system
- therapeutic strategies
