Cellular Intrinsic Modulators in the Pathogenesis of Cancer and Inflammatory Diseases

Dear Colleagues,

Cellular signaling pathways within the human body are complex, as cells undergo several physiological changes, and a harmonic co-ordination among the cellular intrinsic modulators is desirable for better functional outcomes. Cellular intrinsic modulators refer to molecules or mechanisms within a cell that regulate its own activities or functions. These modulators can influence various cellular processes, including gene expression, signal transduction, metabolism, and cell growth. Some of the key intrinsic modulators, including kinases, G-proteins, cyclins, ubiquitin ligases, and cell death regulatory proteins, are under constant surveillance of regulatory mechanisms to maintain cellular homeostasis. Perturbations associated with the expression and functionality of intrinsic modulators trigger human diseases, including cancer and inflammatory diseases. Over the past decade, several studies have been carried out to decrypt structural orientation and molecular interactions of intrinsic modulators that can lead to advances in the understanding of cellular complexity. Moreover, methodological and technological modalities now facilitate the simultaneous analysis of genomic and proteomic profiles from the same single cell to better understand cellular mechanisms.

This Special Issue will cover a wide area of research, investigating the molecular and functional characterization of cellular intrinsic modulators in the regulation of cellular pathways and associated pathological manifestations. Authors are welcome to submit original research articles and reviews covering basic, translational, and preclinical studies.

Prof. Chandramani Pathak is a senior scientist, who will assist Dr. Kishu Ranjan in managing this Special Issue. 

Potential topics include (but are not limited to):

• Transcription factors.
• Kinases and phosphatases.
• G-proteins.
• Second messengers: cyclic AMP (cAMP), calcium ions (Ca²⁺), and inositol trisphosphate (IP3).
• MicroRNAs (miRNAs).
• Epigenetic modifiers: DNA methylation, histone modifications, and chromatin remodeling complexes.
• Proteases and ubiquitin ligases.
• Multi-omics (single cell biology).

Dr. Kishu Ranjan
Guest Editor

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• cancer
• immunobiology
• chronic diseases
• CRISPR
• drug discovery
• multi-omics