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Colorectal Cancers: An Update on Their Molecular Pathology and Therapy

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 20 October 2024 | Viewed by 1298

Special Issue Editor


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Guest Editor
Department of Surgical Clinical Science, Faculty of Medicine, Wroclaw University of Science and Technology, 50-370 Wroclaw, Poland
Interests: colorectal cancers; thymoma; pulmonary medicine; malignant pleural effusion; video-assisted thoracic surgery; mesothelioma; transthoracic biopsy: bronchoscopy; cancer malnutrition; dietary intervention; cachexia; parenteral nutrition
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Special Issue Information

Dear Colleagues,

Colorectal cancer (CRC) is the 3rd most common cancer in Poland. Its incidence is still increasing. The development of colorectal cancer usually takes several years. There are many risk factors for CRC, which could be eliminated by changing one’s lifestyle. Early symptoms are rectal bleeding, change in bowel habits, and abdominal pain. Faecal occult blood tests and colonoscopy once every 10 years reduces the incidence and mortality of CRC. Modern surgical techniques and new oncological drugs improve the quality of life and increase the survival rate. Proper preoperative arrangements reduce the risk of complications and improve surgical results. Patients with CRC are often at increased risk of anxiety and depression.

This Special Issue is open for submissions from any interested individuals. It is expected that contributions will include original research papers, authoritative and up-to-date reviews, and commentaries on the following topics and areas:

  • Novel drugs and surgical techniques for therapy of colorectal disease.
  • Molecular mechanisms for anti-colorectal cancer or cancer-preventive effects.
  • In vitro, in vivo, and clinical studies related to colorectal cancer.
  • Usage of surgical methods in conjunction with cancer chemotherapeutic drugs.
  • Challenges and innovative approaches for anti-colorectal cancer drug development.
  • Novel strategies for colorectal cancer prevention and intervention.
  • Production of anti-colorectal cancer agents using biotechnology.
  • Pharmacokinetics and pharmacogenomic studies on anti-colorectal cancer drugs.

Dr. Mariusz Chabowski
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (1 paper)

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Review

20 pages, 1538 KiB  
Review
Managing Colorectal Cancer from Ethology to Interdisciplinary Treatment: The Gains and Challenges of Modern Medicine
by Monika Berbecka, Maciej Berbecki, Anna Maria Gliwa, Monika Szewc and Robert Sitarz
Int. J. Mol. Sci. 2024, 25(4), 2032; https://doi.org/10.3390/ijms25042032 - 7 Feb 2024
Viewed by 1015
Abstract
Colorectal cancer (CRC) is a common malignant tumor of the gastrointestinal tract, which has become a serious threat to human health worldwide. This article exhaustively reviews colorectal cancer’s incidence and relevance, carcinogenesis molecular pathways, up-to-date treatment opportunities, prophylaxis, and screening program achievements, with [...] Read more.
Colorectal cancer (CRC) is a common malignant tumor of the gastrointestinal tract, which has become a serious threat to human health worldwide. This article exhaustively reviews colorectal cancer’s incidence and relevance, carcinogenesis molecular pathways, up-to-date treatment opportunities, prophylaxis, and screening program achievements, with attention paid to its regional variations and changes over time. This paper provides a concise overview of known CRC risk factors, including familial, hereditary, and environmental lifestyle-related risk factors. The authors take a closer look into CRC’s molecular genetic pathways and the role of specific enzymes involved in carcinogenesis. Moreover, the role of the general practitioner and multidisciplinary approach in CRC treatment is summarized and highlighted based on recent recommendations and experience. This article gives a clear understanding and review of the gains and challenges of modern medicine towards CRC. The authors believe that understanding the current patterns of CRC and its revolution is imperative to the prospects of reducing its burden through cancer prevention and cancer-adjusted treatment. Full article
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