New Molecular Insights into the Gut Microbiome

Dear Colleagues,

The human gut microbiome is closely linked to various immuno-metabolic disorders. It plays an essential role in the transformation and absorption of dietary nutrients, metabolic homeostasis of the host, and changes in immune profiles by producing microbial metabolites and microbe-associated macromolecules. The gut microbiota is responsible for the production of short-chain fatty acids, secondary bile acids, and amino acid metabolites, which control insulin resistance, liver steatosis, gut permeability, and neurotransmitter production through GPCR, FXR, GLP-1, and the serotonin signaling pathway. Additionally, some bacterial strains produce extracellular polysaccharides, peptidoglycans, and exosomes that modulate the host's immune system in autoimmune diseases and cancer, thereby enhancing the differentiation and function of specific immune cell populations. A better understanding of the molecular mechanisms of the gut microbiome will provide valuable information for further translational research and the development of microbiome therapeutics.This Special Issue, entitled “New Molecular Insights in Gut Microbiome”, will focus on the molecular mechanisms and MoA of the gut microbiome in the pathogenesis of immuno-metabolic diseases. Original research and review papers related to various aspects of biochemistry, molecular biology, pharmacology, physiology, and pathology will be considered for this Special Issue.

Prof. Dr. Hyunju You
Guest Editor

Manuscript Submission Information

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• microbiome
• gut microbiota
• nutraceuticals
• immuno-metabolic diseases