Metabolic Mechanisms of Cardiac Injury
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 30 June 2024 | Viewed by 946
Special Issue Editor
Interests: heart; heart metabolism; ischemic heart disease; energy metabolism; atherosclerosis; purine metabolism; AMP deaminase; cardiac hypoxia; heart failure; cardiovascular pharmacology; heart metabolism modulation
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The hearts of adult mammals can hardly regenerate after cardiac injury, which is associated with the irreversible loss of viable cardiomyocytes. Myocardial injury leads to disturbed contractility of the remaining living myocardium, detrimental cardiac remodeling, and, as a result, heart failure. A focus on the changes in myocardial energy metabolism, including fatty acid, glucose, and amino acid metabolism, in cardiac physiological and pathological states is crucial. Metabolites are not only a source of energy but also become critical regulators of gene expression and epigenetic patterns, which may affect heart regeneration.
Understanding the metabolic mechanisms of cardiac injury is critical to the development of diagnostic, treatment, and preventive strategies in the cardiology field. It is essential to promote endogenous regeneration of the heart to improve the prognosis of patients with cardiac injury and to find effective therapeutic strategies for it. However, the metabolic pathways of cardiac damage and heart failure are still elusive, and novel metabolic defects and pathways remain to be identified for screening, molecular diagnosis, drug-target development, and personalized medicine.
This Special Issue focuses on the role of energy metabolism in cardiac injury, intending to shed light on strategies for manipulating heart metabolism and promoting heart repair after cardiac injury.
Dr. Magdalena A. Zabielska-Kaczorowska
Guest Editor
Manuscript Submission Information
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Keywords
- heart metabolism
- fatty acid metabolism
- glucose metabolism
- amino acid metabolism
- metabolism regulation
- mitochondria
