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Research on Skeletal and Cardiac Muscle Regeneration Mechanisms

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: 30 August 2024 | Viewed by 771

Special Issue Editor


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Guest Editor
Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine, LT-08410 Vilnius, Lithuania
Interests: cell death; survival mechanisms; intracellular signaling pathways; oxidative stress; adult human mesenchymal stem/stromal cells; tissue regeneration
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Special Issue Information

Dear Colleagues,

The myogenic and cardiomyogenic differentiations of mesenchymal or other types of stem cells in vitro and in vivo are complex processes, which include cell responsiveness to various compounds and model systems, and direct or indirect interaction between cells and extracellular components, that further regulates intracellular signalling systems and tissue functioning. Despite their diversity, the regeneration mechanisms of skeletal and cardiac muscle occur within the striated muscle environment, whose primary goal is in vitro targeted regulation and subsequent in vivo translation, thereby allowing to improve muscle functioning.

In order to better understand the myogenic and cardiomyogenic differentiation processes and their regulation, both in vivo and in vitro myogenic model systems are of crucial importance. Therefore, this Special Issue aims to collate papers focusing on in vivo and in vitro myogenic and cardiomyogenic differentiation mechanisms that highlight new external or internal inductors, cell types, ECM components, scaffolds and other biomodulators to improve the regeneration of skeletal and cardiac muscles and expand their further clinical applications.

Dr. Daiva Bironaité
Guest Editor

Manuscript Submission Information

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Published Papers (1 paper)

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Research

15 pages, 4833 KiB  
Article
The Transcription Factor Mohawk Facilitates Skeletal Muscle Repair via Modulation of the Inflammatory Environment
by Cherie Alissa Lynch, Sofia A. Acosta, Douglas M. Anderson, Gavin E. Rogers, Jeanne Wilson-Rawls and Alan Rawls
Int. J. Mol. Sci. 2024, 25(9), 5019; https://doi.org/10.3390/ijms25095019 - 4 May 2024
Viewed by 379
Abstract
Efficient repair of skeletal muscle relies upon the precise coordination of cells between the satellite cell niche and innate immune cells that are recruited to the site of injury. The expression of pro-inflammatory cytokines and chemokines such as TNFα, IFNγ, CXCL1, and CCL2, [...] Read more.
Efficient repair of skeletal muscle relies upon the precise coordination of cells between the satellite cell niche and innate immune cells that are recruited to the site of injury. The expression of pro-inflammatory cytokines and chemokines such as TNFα, IFNγ, CXCL1, and CCL2, by muscle and tissue resident immune cells recruits neutrophils and M1 macrophages to the injury and activates satellite cells. These signal cascades lead to highly integrated temporal and spatial control of muscle repair. Despite the therapeutic potential of these factors for improving tissue regeneration after traumatic and chronic injuries, their transcriptional regulation is not well understood. The transcription factor Mohawk (Mkx) functions as a repressor of myogenic differentiation and regulates fiber type specification. Embryonically, Mkx is expressed in all progenitor cells of the musculoskeletal system and is expressed in human and mouse myeloid lineage cells. An analysis of mice deficient for Mkx revealed a delay in postnatal muscle repair characterized by impaired clearance of necrotic fibers and smaller newly regenerated fibers. Further, there was a delay in the expression of inflammatory signals such as Ccl2, Ifnγ, and Tgfß. This was coupled with impaired recruitment of pro-inflammatory macrophages to the site of muscle damage. These studies demonstrate that Mkx plays a critical role in adult skeletal muscle repair that is mediated through the initial activation of the inflammatory response. Full article
(This article belongs to the Special Issue Research on Skeletal and Cardiac Muscle Regeneration Mechanisms)
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