New Therapeutic Approaches for Cerebrovascular Diseases Using Genetic and Nanomolecular Tools
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 20 September 2024 | Viewed by 1765
Special Issue Editor
Interests: ageing; cerebrovascular diseases; cell therapies; gene therapy; behavioral recovery; genomics; proteomics
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Cerebrovascular diseases are the world's second leading cause of death. Stroke can be devastating not only to the patient but also to their families, caregivers, businesses, and social networks. Despite massive research investment, the only available therapeutic options are mechanical thrombectomy and tissue plasminogen activator thrombolysis. Currently, we have a limited understanding of the molecular and cellular processes underlying ischemic stroke recovery. Because of this and other factors, none of the over a thousand medications tested in animal models have been successful in clinical trials. Recent achievements in the understanding of molecular events involved in the pathogenesis of the central nervous system (CNS) injury have made gene therapy, including siRNAs and nanodrugs, a promising approach for various neurological disorders, including cerebrovascular diseases. However, special obstacles, including the post-mitotic nature of neurons and the blood-brain barrier (BBB), constitute key challenges for gene delivery to the CNS. In this special issue, we invite groups working on various forms of gene therapy as well as those groups developing new, more efficient viral vectors for therapeutic purposes to submit their recent work, thus making their achievements available to clinicians and scientists working with animal models of cerebrovascular diseases.
Prof. Dr. Aurel Popa-Wagner
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- cerebrovascular diseases
- stroke
- ischemic stroke
- ischemic stroke
- central nervous system (CNS)
- neurological disorders
