Stroke Life Style: Advancing Our Understanding of Disease Mechanism and Therapy
A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Vascular Medicine".
Deadline for manuscript submissions: closed (31 January 2021) | Viewed by 11451
Special Issue Editor
Interests: ageing; cerebrovascular diseases; cell therapies; gene therapy; behavioral recovery; genomics; proteomics
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Old age is associated with an enhanced susceptibility to stroke, and aged animals recover poorly from brain injuries as compared to young rodents. Despite the initial hope that cell-based therapies may stimulate restorative processes in the ischemic brain, it is now recognized that aging processes may promote an unfavorable environment for such treatments. Virtually all drug interventions that have been successful preclinically in experimental stroke have failed to translate this success to the clinical setting. The failure to consider the complexity and heterogeneity of human diseases and co-morbidities may render neuroprotective drugs less efficacious in clinical practice. It is becoming evident that subtle but continuous neuroinflammation can provide the ground for disorders such as cerebral small vessel disease (cSVD) and subsequently dementia. Moreover, advanced aging and a number of highly prevalent risk factors such as obesity hypertension, diabetes, and atherosclerosis are increasingly understood to act as “silent contributors” to neuroinflammation—not only establishing the condition as a central pathophysiological mechanism, but also constantly fueling it. Acute neuroinflammation, often in the context of traumatic or ischemic CNS lesions, aggravates the acute damage and can lead to a number of pathological illnesses, such as depression, post-stroke dementia and potentially neurodegeneration. All of those sequelae impair recovery and most of them provide the ground for further cerebrovascular events; thus, a vicious cycle develops. We also cover brain vasculature recent advances in signaling pathways that can potentially protect cells as well as treatment options for the maintenance of brain capillaries to prevent diseases associated with brain vasculature remodeling in response to aging and associated comorbidities.
This Special Issue of JCM will provide an up-to-date information on molecular, cellular, and behavioral events associated with stroke epidemiology and new therapeutic options for treatment options.
Prof. Dr. Aurel Popa-Wagner
Guest Editor
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Keywords
- aging
- stroke, epidemiology
- co-morbidities
- hyperlipidemia
- diabetes
- hypertension
- treatment