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Predictive, Prognostic Biomarkers and Therapeutic Targets of Breast Cancer

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".

Deadline for manuscript submissions: 20 September 2024 | Viewed by 917

Special Issue Editors


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Guest Editor
Department of Radiation Oncology, Ospedale San Filippo Neri, ASL Rome 1, Rome, Italy
Interests: radiotherapy; breast cancer; stereotactic body radiotherapy; palliative radiotherapy target therapy; immunotherapy; tailored systemic therapy

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Guest Editor
1. Department of Radiation Oncology, Weill Cornell Medicine, New York, NY, USA
2. Department of Radiation Oncology, Miulli General Regional Hospital, Acquaviva delle Fonti, Bari, Italy
Interests: radiotherapy; breast cancer; stereotactic body radiotherapy; brain radiosurgery; target therapy; immunotherapy; tailored systemic therapy

Special Issue Information

Dear Colleagues,

Breast cancer is the most common cancer in women worldwide, with a high prevalence and incidence, configuring an important issue in cancer epidemiology. Over the years, new diagnostic, surgical and radiation techniques, more effective systemic treatments, and a better understanding of the disease biology and its complexity have improved both the survival and quality of life of breast cancer patients. However, the continuous research in the biological-molecular as well as clinical-translational fields constitute a projection towards the development of possible future treatments.

The scope of this Special Issue is to summarize and enlarge the knowledge in predictive, prognostic biomarkers and therapeutic targets in breast cancer, mostly focus on the interaction of radiotherapy (including stereotactic body radiotherapy and brain radiosurgery) and tailored systemic therapy.

Therefore, on these contexts, authors are invited to submit original research and review articles which address the progress and current standing of cellular signalling and molecular insights.

Dr. Antonella Ciabattoni
Dr. Fabiana Gregucci
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • radiotherapy
  • breast cancer
  • stereotactic body radiotherapy
  • brain radiosurgery
  • target therapy
  • immunotherapy
  • tailored systemic therapy

Published Papers (1 paper)

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Research

11 pages, 563 KiB  
Communication
The Diagnostic Value of microRNA Expression Analysis in Detecting Intraductal Papillomas in Patients with Pathological Nipple Discharge
by Seher Makineli, Menno R. Vriens, Arjen J. Witkamp, Paul J. van Diest and Cathy B. Moelans
Int. J. Mol. Sci. 2024, 25(3), 1812; https://doi.org/10.3390/ijms25031812 - 2 Feb 2024
Viewed by 629
Abstract
Patients with pathological nipple discharge (PND) often undergo local surgical procedures because standard radiologic imaging fails to identify the underlying cause. MicroRNA (MiRNA) expression analysis of nipple fluid holds potential for distinguishing between breast diseases. This study aimed to compare miRNA expression levels [...] Read more.
Patients with pathological nipple discharge (PND) often undergo local surgical procedures because standard radiologic imaging fails to identify the underlying cause. MicroRNA (MiRNA) expression analysis of nipple fluid holds potential for distinguishing between breast diseases. This study aimed to compare miRNA expression levels between nipple fluids from patients with PND to identify possible relevant miRNAs that could differentiate between intraductal papillomas and no abnormalities in the breast tissue. Nipple fluid samples from patients with PND without radiological and pathological suspicion for malignancy who underwent a ductoscopy procedure were analyzed. We used univariate and multivariate regression analyses to identify nipple fluid miRNAs differing between pathologically confirmed papillomas and breast tissue without abnormalities. A total of 27 nipple fluid samples from patients with PND were included for miRNA expression analysis. Out of the 22 miRNAs examined, only miR-145-5p was significantly differentially expressed (upregulated) in nipple fluid from patients with an intraductal papilloma compared to patients showing no breast abnormalities (OR 4.76, p = 0.046), with a diagnostic accuracy of 92%. miR-145-5p expression in nipple fluid differs for intraductal papillomas and breast tissue without abnormalities and, therefore, has potential as a diagnostic marker to signal presence of papillomas in PND patients. However, further refinement and validation in clinical trials are necessary to establish its clinical applicability. Full article
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