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Heart-Brain Interaction: Atrial Fibrillation and Stroke

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 15 May 2024 | Viewed by 1317

Special Issue Editors


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Guest Editor
Department of Anaesthesiology and Intensive Care, Medical School, University of Pecs, 7624 Pecs, Hungary
Interests: intensive care; subarachnoid hemorrhage; delayed cerebral ischemia; traumatic brain injury
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Guest Editor
Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Rome, Italy
Interests: intensive care medicine; stroke; mechanical ventilation; artificial intelligence

Special Issue Information

Dear Colleagues,

The interaction between the heart and the brain is complicated and closely interconnected. In considering the impact of cerebrovascular disease on patients’ wellbeing and health resources, the molecular and pathological mechanisms underlying heart–brain interaction need to be further investigated. The identification of novel and cross-talking physiologic processes is crucial to manage vascular risk, correct timing of intervention and interdependence among illnesses. A well-established association between the heart and the brain is represented by cardiac embolisms, which account for a large porportion of all ischemic strokes. Atrial fibrillation (AF) is the most relevant risk factor for cardiac embolisms and a leading cause of ischemic stroke, heart failure and sudden death. Consequently, a more comprehensive understanding of its association with cerebrovascular disease is also needed. For this Special Issue, we invite submissions including research articles, reviews and communications on a wide range of topics. Submissions of interdisciplinary or multi-modal research papers regarding the mechanisms of brain–heart interaction are particularly welcomed.

Prof. Dr. Tihamér Molnár
Dr. Giovanna Mercurio
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

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Keywords

  • stroke
  • atrial fibrillation
  • cerebrovascular disease
  • heart–brain interaction

Published Papers (1 paper)

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Research

16 pages, 2597 KiB  
Article
Combined Metabolipidomic and Machine Learning Approach in a Rat Model of Stroke Reveals a Deleterious Impact of Brain Injury on Heart Metabolism
by Xavier Dieu, Sophie Tamareille, Aglae Herbreteau, Lucie Lebeau, Juan Manuel Chao De La Barca, Floris Chabrun, Pascal Reynier, Delphine Mirebeau-Prunier and Fabrice Prunier
Int. J. Mol. Sci. 2023, 24(15), 12000; https://doi.org/10.3390/ijms241512000 - 26 Jul 2023
Viewed by 864
Abstract
Cardiac complications are frequently found following a stroke in humans whose pathophysiological mechanism remains poorly understood. We used machine learning to analyse a large set of data from a metabolipidomic study assaying 630 metabolites in a rat stroke model to investigate metabolic changes [...] Read more.
Cardiac complications are frequently found following a stroke in humans whose pathophysiological mechanism remains poorly understood. We used machine learning to analyse a large set of data from a metabolipidomic study assaying 630 metabolites in a rat stroke model to investigate metabolic changes affecting the heart within 72 h after a stroke. Twelve rats undergoing a stroke and 28 rats undergoing the sham procedure were investigated. A plasmatic signature consistent with the literature with notable lipid metabolism remodelling was identified. The post-stroke heart showed a discriminant metabolic signature, in comparison to the sham controls, involving increased collagen turnover, increased arginase activity with decreased nitric oxide synthase activity as well as an altered amino acid metabolism (including serine, asparagine, lysine and glycine). In conclusion, these results demonstrate that brain injury induces a metabolic remodelling in the heart potentially involved in the pathophysiology of stroke heart syndrome. Full article
(This article belongs to the Special Issue Heart-Brain Interaction: Atrial Fibrillation and Stroke)
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