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Molecular Advances in Oral Biofilms

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Microbiology".

Deadline for manuscript submissions: 15 June 2024 | Viewed by 1125

Special Issue Editors


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Guest Editor
Vice-Provost for Research, Federal University of Rio Grande do Sul, Porto Alegre 91501-970, Brazil
Interests: microbiology

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Co-Guest Editor
Department of Stomatology, School of Dentistry, Federal University of Goiás, Goiânia, GO, Brazil
Interests: dental pulp inflammation; apical periodontitis; root canal microbiology; clinical endodontic diagnostic; oral radiology; dental pulp and apical tissues immunology; molecular oral biology; oral biofilms

Special Issue Information

Dear Colleagues,

The role of oral biofilms as the main cause for oral and dental infections is well known. However, our knowledge on this topic needs to improve in order to obtain a complete understanding of the onset, molecular mechanisms, conditions which microorganisms adhere to biofilm, their specific and general roles and how to prevent and treat each one. This Special Issue invites researchers, clinicians and specialists in various fields of biological and health sciences to submit articles that discuss novel information and recent advances in oral biofilms. A plethora of methodologies are welcome, having molecular techniques as the mainstream, which can be entwined with basic, clinical or translational research, as well as solid reviews. With this Special Issue, we are confident that readers will be able to gauge the extent of situations in which molecular advances provide knowledge on how oral biofilms are formed or involved in oral diseases. The International Journal of Molecular Sciences invites you to join us on this journey towards molecular advances in oral biofilms. Since IJMS is a journal of molecular science, thus pure clinical studies will not be suitable for our journal. But clinical submissions with biomolecular experiments are welcomed.

Prof. Dr. José Antonio Poli De Figueiredo
Dr. Carlos Estrela
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biofilms
  • oral tissues
  • dental tissues
  • molecular basis
  • dentine
  • enamel
  • microorganisms
  • prevention
  • treatment

Published Papers (1 paper)

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Research

14 pages, 1906 KiB  
Article
Inhibitory Effects of Shikonin Dispersion, an Extract of Lithospermum erythrorhizon Encapsulated in β-1,3-1,6 Glucan, on Streptococcus mutans and Non-Mutans Streptococci
by Ryota Nomura, Yuto Suehiro, Fumikazu Tojo, Saaya Matayoshi, Rena Okawa, Masakazu Hamada, Shuhei Naka, Michiyo Matsumoto-Nakano, Rika Unesaki, Kazuya Koumoto, Keiko Kawauchi, Takahito Nishikata, Tatsuya Akitomo, Chieko Mitsuhata, Masatoshi Yagi, Toshiro Mizoguchi, Koki Fujikawa, Taizo Taniguchi and Kazuhiko Nakano
Int. J. Mol. Sci. 2024, 25(2), 1075; https://doi.org/10.3390/ijms25021075 - 16 Jan 2024
Viewed by 910
Abstract
Shikonin is extracted from the roots of Lithospermum erythrorhizon, and shikonin extracts have been shown to have inhibitory effects on several bacteria. However, shikonin extracts are difficult to formulate because of their poor water solubility. In the present study, we prepared a [...] Read more.
Shikonin is extracted from the roots of Lithospermum erythrorhizon, and shikonin extracts have been shown to have inhibitory effects on several bacteria. However, shikonin extracts are difficult to formulate because of their poor water solubility. In the present study, we prepared a shikonin dispersion, which was solubilized by the inclusion of β-1,3-1,6 glucan, and analysed the inhibitory effects of this dispersion on Streptococcus mutans and non-mutans streptococci. The shikonin dispersion showed pronounced anti-S. mutans activity, and inhibited growth of and biofilm formation by this bacterium. The shikonin dispersion also showed antimicrobial and antiproliferative effects against non-mutans streptococci. In addition, a clinical trial was conducted in which 20 subjects were asked to brush their teeth for 1 week using either shikonin dispersion-containing or non-containing toothpaste, respectively. The shikonin-containing toothpaste decreased the number of S. mutans in the oral cavity, while no such effect was observed after the use of the shikonin-free toothpaste. These results suggest that shikonin dispersion has an inhibitory effect on S. mutans and non-mutans streptococci, and toothpaste containing shikonin dispersion may be effective in preventing dental caries. Full article
(This article belongs to the Special Issue Molecular Advances in Oral Biofilms)
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