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Molecular Research on Diabetic Wound Healing

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: closed (15 December 2023) | Viewed by 1819

Special Issue Editors


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Guest Editor
Center for Neuroscience and Cell Biology, Faculty of Medicine, University of Coimbra, Rua Larga, Polo I, 1st Floor, 3004-504 Coimbra, Portugal
Interests: diabetes; diabetic complications; wound healing; immunomodulation; inflammation; angiogenesis; stem cells; infection; aging; quality control; metabolism; signaling pathways
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E-Mail Website
Guest Editor
Center for Neuroscience and Cell Biology, Faculty of Medicine, University of Coimbra, Rua Larga, Polo I, 1st Floor, 3004-504 Coimbra, Portugal
Interests: diabetes and complications; wound healing; obesity; insulin resistance; inflammation; immunosuppressive agents; metabolism; signaling pathways

Special Issue Information

Dear Colleagues,

Wound healing is a complex biological process that entails several well-coordinated sequential stages regulated by numerous molecular factors. In diabetic wounds, these molecular factors are altered, which impairs the healing process and causes delayed or non-healing chronic wounds.

Diabetic foot ulcer (DFU) is a major complication of diabetes and the main cause of incapacity and morbidity in increasing numbers of diabetic patients worldwide. Due to the complexity of wound healing, DFU poses a medical challenge, and current therapies have a limited efficacy and are scarce. Therefore, understanding the molecular mechanisms of impaired diabetic wound healing will allow for the development of targeted treatments that can greatly improve the quality of life of patients and reduce the cost associated with this condition.

In this Special Issue, we welcome both basic and translational research on the molecular mechanisms of diabetic wound healing and novel molecules with potential to became specific targets for future therapeutic interventions. We encourage the submission of original research articles or critical reviews and aim to discuss emerging research directions. We expect that these studies will foster innovative advances from bench to bedside.

Dr. Ermelindo C. Leal
Dr. Eugénia Carvalho
Guest Editors

Manuscript Submission Information

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Keywords

  • diabetic wound healing
  • molecular pathways
  • inflammation
  • angiogenesis
  • infection
  • extracellular matrix

Published Papers (1 paper)

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Review

24 pages, 4424 KiB  
Review
Fibroblasts in Diabetic Foot Ulcers
by Francesca A. Voza, Carlos Theodore Huerta, Nga Le, Hongwei Shao, Antoine Ribieras, Yulexi Ortiz, Carl Atkinson, Tiago Machuca, Zhao-Jun Liu and Omaida C. Velazquez
Int. J. Mol. Sci. 2024, 25(4), 2172; https://doi.org/10.3390/ijms25042172 - 11 Feb 2024
Viewed by 1290
Abstract
Fibroblasts are stromal cells ubiquitously distributed in the body of nearly every organ tissue. These cells were previously considered to be “passive cells”, solely responsible for ensuring the turnover of the extracellular matrix (ECM). However, their versatility, including their ability to switch phenotypes [...] Read more.
Fibroblasts are stromal cells ubiquitously distributed in the body of nearly every organ tissue. These cells were previously considered to be “passive cells”, solely responsible for ensuring the turnover of the extracellular matrix (ECM). However, their versatility, including their ability to switch phenotypes in response to tissue injury and dynamic activity in the maintenance of tissue specific homeostasis and integrity have been recently revealed by the innovation of technological tools such as genetically modified mouse models and single cell analysis. These highly plastic and heterogeneous cells equipped with multifaceted functions including the regulation of angiogenesis, inflammation as well as their innate stemness characteristics, play a central role in the delicately regulated process of wound healing. Fibroblast dysregulation underlies many chronic conditions, including cardiovascular diseases, cancer, inflammatory diseases, and diabetes mellitus (DM), which represent the current major causes of morbidity and mortality worldwide. Diabetic foot ulcer (DFU), one of the most severe complications of DM affects 40 to 60 million people. Chronic non-healing DFU wounds expose patients to substantial sequelae including infections, gangrene, amputation, and death. A complete understanding of the pathophysiology of DFU and targeting pathways involved in the dysregulation of fibroblasts are required for the development of innovative new therapeutic treatments, critically needed for these patients. Full article
(This article belongs to the Special Issue Molecular Research on Diabetic Wound Healing)
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