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Physiopathology of Connective Tissue: Regenerative Perspective
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Physiopathology of Connective Tissue: Regenerative Perspective

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 20 October 2024 | Viewed by 2024

Special Issue Editor

Dr. Carmelo Pirri

E-Mail Website
Guest Editor
Department of Neurosciences, Institute of Human Anatomy, University of Padova, 35121 Padua, Italy
Interests: fascial physiopathology; fascial ultrasonography; connective tissue; molecular medicine; regenerative medicine; ultrasound imaging; rehabilitation; sports injuries; biomechanics; pain medicine; neurorehabilitation; musculoskeletal disorders
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues, 

Connective tissue is the most widespread tissue in the body, it constitutes more than half of the human body weight and has a high functional activity, including metabolic and immunological ones. The regenerative potential of connective tissue as a basis for physiological renewal and repair processes in the effective healing of damaged tissues and organs in the body is crucial.

The structure and the functions of connective tissue can be damaged by the stress of various genesis, genetic factors, age, diet and other factors, leading to numerous and often serious disorders with a long chronic course, especially when other tissues and organs that depend on it are affected.

The knowledge of connective tissue in histophysiology, biochemistry and molecular biology is of both fundamental scientific interest and applied relevance in clinical medicine. Therefore, its better comprehensive understanding can promote new discoveries in the field of studying the body's internal processes.

Thus, this Special Issue intends to include both physiopathology of connective tissue and translational advances in the regenerative field. In addition to original articles, reviews, case reports and case series articles evaluating advanced therapies are also welcomed.

Dr. Carmelo Pirri
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • connective tissue
  • physiopathology
  • molecular medicine
  • regenerative medicine
  • healing
  • collagen
  • hyaluronan

Published Papers (1 paper)

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Research

12 pages, 4700 KiB  
Article
A New Player in the Mechanobiology of Deep Fascia: Yes-Associated Protein (YAP)
by Carmelo Pirri, Brasilina Caroccia, Andrea Angelini, Maria Piazza, Lucia Petrelli, Ilaria Caputo, Chiara Montemurro, Pietro Ruggieri, Raffaele De Caro and Carla Stecco
Int. J. Mol. Sci. 2023, 24(20), 15389; https://doi.org/10.3390/ijms242015389 - 20 Oct 2023
Cited by 2 | Viewed by 1184
Abstract
Recent studies have demonstrated that fascial fibroblasts are susceptible to mechanical stimuli, leading to the remodeling of the extracellular matrix (ECM). Moreover, the extensive literature on Yes-associated protein (YAP) has shown its role in cell mechanics, linking cell properties, such as shape, adhesion, [...] Read more.
Recent studies have demonstrated that fascial fibroblasts are susceptible to mechanical stimuli, leading to the remodeling of the extracellular matrix (ECM). Moreover, the extensive literature on Yes-associated protein (YAP) has shown its role in cell mechanics, linking cell properties, such as shape, adhesion, and size, to the expression of specific genes. The aim of this study was to investigate the presence of YAP in deep fascia and its activation after a mechanical stimulus was induced via a focal extracorporeal shockwave (fESW) treatment. Thoracolumbar fascia (TLF) samples were collected from eight patients (age: 30–70 years; four males and four females) who had undergone spine elective surgical procedures at the Orthopedic Clinic of University of Padova. YAP was measured in both tissue and TLF-derived fibroblasts through immunoblotting. COL1A1 and HABP2 gene expression were also evaluated in fibroblasts 2, 24, and 48 h after the fESW treatment. YAP was expressed in all the examined tissues. The ratio between the active/inactive forms (YAP/p-YAP) of the protein significantly increased in fascial fibroblasts after mechanical stimulation compared to untreated cells (p = 0.0022). Furthermore, COL1A1 and HABP2 gene expression levels were increased upon treatment. These findings demonstrate that YAP is expressed in the deep fascia of the thoracolumbar region, suggesting its involvement in fascial mechanotransduction processes, remodeling, regeneration, and fibrogenesis. This study indicates, for the first time, that YAP is a “new player” in the mechanobiology of deep fascia. Full article
(This article belongs to the Special Issue Physiopathology of Connective Tissue: Regenerative Perspective)
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