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Endometriosis: From Molecular Basis to Therapy
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Endometriosis: From Molecular Basis to Therapy

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: closed (30 April 2024) | Viewed by 1826

Special Issue Editor

Prof. Dr. Grzegorz Polak

E-Mail Website
Guest Editor
Independent Laboratory of Minimally Invasive Gynecology and Gynecological Endocrinology Medical University of Lublin, Staszica 16, 20-081 Lublin, Poland
Interests: endometriosis; ovarian; gynecology

Special Issue Information

Dear Colleagues,

Endometriosis is a polymorphous and subtle pathology that affects 1 in 10 women worldwide. Endometriosis-related pain severely affects peoples’ quality of life by impairing working efficiency, social life and sexual function, among others. According to the type and location of the lesions, endometriosis is subdivided into peritoneal endometriosis, deep endometriosis and endometrioma. Although research has improved our knowledge of the genetic and molecular pathways involved in the establishment and progression of endometriosis, the pathogenesis of this condition remains yet to be fully understood.

This Specia Issue of IJMS, led by Prof. Dr. Grzegorz Polak, aims to highlight the recent insights and discoveries, novel developments, current challenges, and future perspectives in the field of endometriosis. We cordially invite submissions of papers addressing any and all relevant aspects of this condition’s pathology. 

Prof. Dr. Grzegorz Polak
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • endometriosis
  • endometriosis diagnosis
  • infertility
  • novel strategies

Published Papers (2 papers)

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Review

14 pages, 1366 KiB  
Review
Immune Dysregulation in Endometriomas: Implications for Inflammation
by Izabela Dymanowska-Dyjak, Barbara Terpiłowska, Izabela Morawska-Michalska, Adam Michalski, Grzegorz Polak, Michał Terpiłowski, Mansur Rahnama-Hezavah and Ewelina Grywalska
Int. J. Mol. Sci. 2024, 25(9), 4802; https://doi.org/10.3390/ijms25094802 - 28 Apr 2024
Viewed by 241
Abstract
The most common manifestation of endometriosis, a condition characterized by the presence of endometrial-like tissue outside of the uterus, is the endometrioma, a cystic ovarian lesion. It is a commonly occurring condition associated with chronic pelvic pain exacerbated prior to and during menstruation, [...] Read more.
The most common manifestation of endometriosis, a condition characterized by the presence of endometrial-like tissue outside of the uterus, is the endometrioma, a cystic ovarian lesion. It is a commonly occurring condition associated with chronic pelvic pain exacerbated prior to and during menstruation, as well as infertility. The exact pathomechanisms of the endometrioma are still not fully understood. Emerging evidence suggests a pivotal role of immune dysregulation in the pathogenesis of endometriomas, primarily influencing both local and systemic inflammatory processes. Among the factors implicated in the creation of the inflammatory milieu associated with endometriomas, alterations in both serum and local levels of several cytokines stand out, including IL-6, IL-8, and IL-1β, along with abnormalities in the innate immune system. While numerous signaling pathways have been suggested to play a role in the inflammatory process linked to endometriomas, only NF-κB has been conclusively demonstrated to be involved. Additionally, increased oxidative stress, both resulting from and contributing to endometriomas, has been identified as a primary driver of both systemic and local inflammation associated with the condition. This article reviews the current understanding of immune dysfunctions in the endometrioma and their implications for inflammation. Full article
(This article belongs to the Special Issue Endometriosis: From Molecular Basis to Therapy)
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15 pages, 688 KiB  
Review
The Efficacy and Safety of Transvaginal Ethanol Sclerotherapy in the Treatment of Endometrial Cysts—A Systematic Review
by Karolina Frankowska, Izabela Dymanowska-Dyjak, Monika Abramiuk and Grzegorz Polak
Int. J. Mol. Sci. 2024, 25(2), 1337; https://doi.org/10.3390/ijms25021337 - 22 Jan 2024
Cited by 2 | Viewed by 1098
Abstract
Endometriosis, as a chronic disorder that is a source of severe pain ailments and infertility, requires a comprehensive therapeutic approach. Sclerotherapy, consisting of the administration of sclerosing agents into the cyst, is a constantly evolving minimally invasive treatment method for this disease. Hence, [...] Read more.
Endometriosis, as a chronic disorder that is a source of severe pain ailments and infertility, requires a comprehensive therapeutic approach. Sclerotherapy, consisting of the administration of sclerosing agents into the cyst, is a constantly evolving minimally invasive treatment method for this disease. Hence, the main objective of this systematic review was to evaluate the impact of its most often used variant, transvaginal ethanol sclerotherapy, on endometriosis-related symptoms, endometrial cyst recurrence rate, ovarian reserve, assisted reproductive technology (ART) outcomes, and pregnancy outcomes, as well as to assess potential complications resulting from this treatment. This systematic review was undertaken using PubMed, Scopus, Web of Science, and Cochrane Library databases on 24 November 2023. The risk of bias in included studies was assessed with the use of the Newcastle–Ottawa scale (NOS) and the revised Cochrane risk of bias 2.0 tool for randomized controlled trials. From the 1141 records obtained from all databases, 16 studies have been included in this review. The use of ethanol sclerotherapy was characterized by a low rate of post-procedural complications. The recurrence rate of endometrial cysts after the procedure depended on the ethanol instillation time within the cyst. Although ethanol sclerotherapy had negligible influence on ovarian reserves when compared to laparoscopic cystectomy, the effects of both these methods on pregnancy outcomes were comparable. This review identifies that sclerotherapy is safe, provides significant relief of symptoms, and does not impair the reproductive potential of the patients. Full article
(This article belongs to the Special Issue Endometriosis: From Molecular Basis to Therapy)
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