Signalling Pathway and Regulation of Oxidative Stress in Lung Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 31 May 2024 | Viewed by 1431
Special Issue Editors
Interests: lung disease; oxidative stress; innate immunity; drug delivery; experimental pharmacology; oxidative stress sensors
Interests: translational pulmonology; immunopathology of lung disease; experimental pharmacology; innate immunity; oxidative stress sensors
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
In the lungs, airway epithelium is the first line of defense against inhaled particles (or inhalants). Exposure to cigarette smoke, allergens, viruses and other environmental contaminants increases airway oxidative stress. Airway epithelium has a central role in the physiopathology of chronic airway diseases, notably asthma and COPD. Increased oxidative stress is associated with the amplification of inflammatory process, tissue damage and alteration of innate and adaptive immunity, thus compromising airway homeostasis. Airway epithelium is a primary target of the anti-inflammatory actions of glucocorticoids. Cigarette smoke and oxidative stress negatively affect pathways associated with steroid response, whereas antioxidants and drugs effective in reducing oxidative stress enhance the response of steroids. This Special Issue will explore the pathways activated by oxidative stress, with particular focus on the mechanisms associated with corticoresistance, with the aim of identifying new pharmacological strategies capable of restoring the oxidant/antioxidant balance.
Dr. Maria Ferraro
Dr. Elisabetta Pace
Guest Editors
Manuscript Submission Information
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Keywords
- oxidative stress
- lung disease
- airway epithelium
- steroid resistance
- antioxidant treatment
