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Advances in Molecular Research on Neuroprotective Approaches to Stroke

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 15 July 2024 | Viewed by 1741

Special Issue Editor


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Guest Editor
Department of Neurology, University of Göttingen Medical School, 37077 Göttingen, Germany
Interests: stroke

Special Issue Information

Dear Colleagues, 

Stroke is a leading cause of death and the most common global source of acquired physical disability. With its changing demographics, the significance of stroke and its consequences continues to grow. The current treatment options are limited to vessel recanalization, and only a small number of patients are eligible for this time-sensitive treatment. Thus, new neuroprotective approaches are urgently needed. Neuroprotection refers to interventions that preserve, restore, or regenerate the nervous system by interrupting the sequence of events triggered by ischemic stroke. Nevertheless, significant research efforts are underway to develop new neuroprotective strategies for the future. This Special Issue focuses on these novel approaches and their underlying molecular mechanisms, a comprehensive understanding of which is critical to successful bench-to-bedside translation in the future.

Dr. Matteo Haupt
Guest Editor

Manuscript Submission Information

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Keywords

  • stroke
  • neuroprotection
  • neuroprotectants
  • neuroregeneration
  • translational research

Published Papers (1 paper)

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Research

20 pages, 5753 KiB  
Article
Extremely Low-Frequency Electromagnetic Stimulation (ELF-EMS) Improves Neurological Outcome and Reduces Microglial Reactivity in a Rodent Model of Global Transient Stroke
by Amanda Moya-Gómez, Lena Pérez Font, Andreea Burlacu, Yeranddy A. Alpizar, Miriam Marañón Cardonne, Bert Brône and Annelies Bronckaers
Int. J. Mol. Sci. 2023, 24(13), 11117; https://doi.org/10.3390/ijms241311117 - 05 Jul 2023
Cited by 2 | Viewed by 1257
Abstract
Extremely low-frequency electromagnetic stimulation (ELF-EMS) was demonstrated to be significantly beneficial in rodent models of permanent stroke. The mechanism involved enhanced cerebrovascular perfusion and endothelial cell nitric oxide production. However, the possible effect on the neuroinflammatory response and its efficacy in reperfusion stroke [...] Read more.
Extremely low-frequency electromagnetic stimulation (ELF-EMS) was demonstrated to be significantly beneficial in rodent models of permanent stroke. The mechanism involved enhanced cerebrovascular perfusion and endothelial cell nitric oxide production. However, the possible effect on the neuroinflammatory response and its efficacy in reperfusion stroke models remains unclear. To evaluate ELF-EMS effectiveness and possible immunomodulatory response, we studied neurological outcome, behavior, neuronal survival, and glial reactivity in a rodent model of global transient stroke treated with 13.5 mT/60 Hz. Next, we studied microglial cells migration and, in organotypic hippocampal brain slices, we assessed neuronal survival and microglia reactivity. ELF-EMS improved the neurological score and behavior in the ischemia-reperfusion model. It also improved neuronal survival and decreased glia reactivity in the hippocampus, with microglia showing the first signs of treatment effect. In vitro ELF-EMS decreased (Lipopolysaccharide) LPS and ATP-induced microglia migration in both scratch and transwell assay. Additionally, in hippocampal brain slices, reduced microglial reactivity, improved neuronal survival, and modulation of inflammation-related markers was observed. Our study is the first to show that an EMF treatment has a direct impact on microglial migration. Furthermore, ELF-EMS has beneficial effects in an ischemia/reperfusion model, which indicates that this treatment has clinical potential as a new treatment against ischemic stroke. Full article
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