Molecular and Translational Research on Bone Tumors 2.0

Dear Colleagues,

Bone tumours can affect every part of the skeleton and can develop in any part of the bone, from the centre to the surface. Their growth can destroy healthy tissue and reduce bone strength, causing pathologic fractures. Primary bone tumours and metastases are characterized by the perturbation of physiological bone remodelling activity by osteoblasts and osteoclasts. The crosstalk between cancer and bone cells allows the growth and the spread of the tumour.

Due to the unknown aetiology, complexity and heterogeneity of most bone tumours, a better understanding of the mechanisms underlying the oncogenesis is still necessary.

This Special Issue will focus both on benign and malignant bone tumours, in particular on:

• The analysis of the molecular and cellular mechanisms leading to the onset of these tumours;
• The identification of new therapeutic approaches;
• The detection of biomarkers for early diagnosis.

Both original research and review articles are welcome.

Dr. Michela Rossi
Dr. Andrea Del Fattore
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• primary bone tumours
• metastatic bone tumour
• therapy
• biomarkers
• epigenetic factors
• immune-oncology