Molecular Research in Viral Hepatitis and Liver Cancer

Dear Colleagues,

Viral hepatitis (mainly hepatitis B, C, and D) has continued to be a global threat. New mechanisms in the pathogenesis of inducing liver diseases have been discovered over the past few decades. One of the major complications of viral hepatitis is hepatocellular carcinoma (HCC), and its mortality rates are rapidly increasing worldwide. Cirrhosis, a chronic complication of viral hepatitis, is also known to be a major risk factor for HCC. Although hepatitis B vaccination and antiviral therapy for hepatitis B and C are effective the for primary prevention of HCCs, unmet clinical needs require further in-depth studies centred around molecular mechanisms. Primary HCC may arise out of synergy between chronic viral infection and other carcinogenic stimuli that induce increased hepatic mitotic activity. Common mechanisms shared by HBV, HCV, and HDV in causing liver cancer include persistent liver inflammation with an impaired anti-viral immune response, viral protein-mediated oxidative stress, and dysregulated cellular signaling pathways. In this Special Issue, investigators provide further evidence in this important field.

Prof. Dr. Teh-Ia Huo
Guest Editor

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• hepatitis B
• hepatitis C
• hepatitis D
• hepatocellular carcinoma