Targeting Blood Vessels in Cancer and Fibrosis
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 30 May 2024 | Viewed by 1197
Special Issue Editor
Interests: tumor angiogenesis; vessel co-option; lung metastases; tissue fibrosis; pericytes
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Blood vessels are tubes that carry blood throughout an organism. Blood supplies oxygen and nutrients to different tissues. Changes in blood vessels occur in different pathologies such as cancer or tissue fibrosis. Tumors need the formation of a fine network of blood vessels to provide nutrients to cancer cells. However, tumor vasculature is normally immature and leaky and generates hypoxia in tumor cells that mediate therapy resistance and metastasis. For this reason, the modulation of tumor vasculature using different strategies such as anti-angiogenesis or vessel normalization is an interesting approach to enhance the efficacy of cancer therapy. Fibrotic diseases in organs such as the lungs, liver, heart or kidneys are characterized by the accumulation of extracellular matrices in the tissue parenchyma and microvascular rarefaction that also lead to tissue hypoxia. The modulation of microvasculature in fibrotic tissues to eliminate hypoxia and control the buildup of extracellular matrix is also being explored.
This Special Issue welcomes original articles and reviews focused on the novelties in the modulation of blood vessels in cancer and fibrotic diseases.
Dr. José M. Muñoz-Félix
Guest Editor
Manuscript Submission Information
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Keywords
- blood vessels
- angiogenesis
- fibrosis
- fibroblasts
- hypoxia
- pericytes
