Advances in Cardiovascular Remodeling
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 29 August 2024 | Viewed by 1722
Special Issue Editor
Interests: marfan syndrome; cardiovascular remodeling; hypertension; aortic disease; heart hypertrophy; diabetes; endoplasmic reticulum stress; mitochondrial stress; cardiotoxicity
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Pathological cardiovascular remodeling is associated with fibrosis, inflammation and cellular dysfunction. Myocardial remodeling (MR) is a deleterious process characterized by gradual cardiac enlargement and cardiac dysfunction produced by the underlying disease process. It is characterized by molecular, cellular and interstitial changes that manifest clinically as changes in size, mass, geometry and function of the heart whereas vascular remodeling is the process of altering structure and arrangement in blood vessels through cell growth, cell death, cell migration, and production or degradation of the ECM. Myocardial fibrosis and vascular disease play an important role in the progression to heart failure and are a primary cause of myocardial infarction, stroke and ischemia. Both are the leading cause of morbidity and mortality in the Western world and a major public health problem in industrialized countries. Moreover, cardiovascular remodeling is accelerated in hypertensive disease, atherosclerosis, diabetes mellitus, chronic kidney disease, inflammatory disease, genetic abnormalities and lifestyle aspects (smoking). In recent years, a large number of preclinical studies have demonstrated that blunting load-induced hypertrophic growth of the left ventricle and reducing vascular hypertrophic remodeling and wall stiffness is possible. These studies have uncovered a potential new target of anti-remodeling therapy, which if true, may be key to impeding the progression of cardiovascular diseases.
Dr. María Galán
Guest Editor
Manuscript Submission Information
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Keywords
- extracellular matrix
- hypertension
- diabetes
- atherosclerosis
- vascular dysfunction
- inflammation
- heart hypertrophy
- heart failure
- biomarkers
- therapeutic targets
