Roles of Extracellular Vesicles in Cerebrovascular Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (30 April 2024) | Viewed by 1393
Special Issue Editor
Special Issue Information
Dear Colleagues,
Cerebrovascular disease is a major contributor to later-life dementia, accounting for up to 20% of cases of dementia. A sedentary lifestyle, hypertension, diabetes, and aging are major risk factors for cerebrovascular diseases. Extracellular vesicles (EVs) are extracellular nanovesicles released by virtually cell lineages. In recent decades, much attention has been devoted to EVs as novel carriers of bioactive molecules such as proteins and genetic materials to influence the functions of cells/tissues nearby and distant. Because of their ability to cross the brain-blood barrier, EVs have the potential to serve as biomarkers and therapeutic carriers to deliver molecules into the brain. Emerging evidence indicates that circulating and brain-derived EVs might play a role in cerebrovascular diseases. However, how the circulating and/or brain-derived EVs secreted in physiological and pathological microenvironments differently affect the interactions of brain cells is largely unknown. In this regard, we invite investigators to contribute original research articles and reviews that stimulate the continuing efforts to understand EVs' roles and potential applications in cerebrovascular diseases such as stroke and hypertension- and aging-related dementia.
As the Guest Editor of this Special Issue, I hope this collection will be a useful reference for understanding EVs' roles and potential application in cerebrovascular diseases and their comorbidities.
We look forward to receiving your contributions.
Dr. Jinju Wang
Guest Editor
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Keywords
- exosomes
- cerebrovascular disease
- stroke
- hypertension-related dementia
- aging-related dementia
