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Recent Advances of Biochemistry and Molecular Biology of Infectious Diseases, 2nd Edition

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 30 July 2024 | Viewed by 2583

Special Issue Editor

Prof. Dr. Salvatore G. De-Simone

E-Mail Website
Guest Editor
Center for Technological Development in Health (CDTS)/National Institute of Science and Technology for Innovation in Neglected Diseases Populations (INCT-IDPN), Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro 21040-900, RJ, Brazil
Interests: microarray of peptides; chimeric proteins; diagnosis; emerging pathogens; target proteins
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue follows the publication of the first edition on “Recent Advances of Biochemistry and Molecular Biology of Infectious Diseases”.

It is a great pleasure to invite you to contribute to this Special Issue titled “Recent Advances of Biochemistry and Molecular Biology of Infectious Diseases”. Recent epidemic outbreaks of emerging, re-emerging, and neglected infectious diseases have demonstrated the importance of applying control and prevention measures. For such actions to be practical, the development of methods resulting from the improvement of molecular biology, biochemistry, and cell biology has leveraged innovation. However, the interpretation of results requires different levels of knowledge that may contribute to the emergence of new technologies, which, in turn, result in the development of new drugs, therapies, and more effective diagnoses. This Special Issue is open to all researchers, but mainly those from Brazil, studying emerging, re-emerging, and neglected infectious diseases at a molecular level. Original articles, as well as new perspectives or reviews, are welcome. Research in the fields of molecular studies in biology and chemistry, biochemistry of vaccines, molecular pathogenesis, genetic mutations, cloning and expression of proteins in plants and other systems, -omics, viral immunology, antiviral drugs, and tools to study these interactions at a molecular level are especially encouraged.

Prof. Dr. Salvatore G. De-Simone
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • SARS-CoV
  • ZIKAV
  • host–parasite interaction
  • molecular diagnostics
  • molecular interactions
  • molecular pathogenesis
  • infectious diseases

Published Papers (2 papers)

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Research

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21 pages, 5124 KiB  
Article
RanBP2/Nup358 Mediates Sumoylation of STAT1 and Antagonizes Interferon-α-Mediated Antiviral Innate Immunity
by Jiawei Li, Lili Su, Jing Jiang, Yifan E. Wang, Yingying Ling, Yi Qiu, Huahui Yu, Yucong Huang, Jiangmin Wu, Shan Jiang, Tao Zhang, Alexander F. Palazzo and Qingtang Shen
Int. J. Mol. Sci. 2024, 25(1), 299; https://doi.org/10.3390/ijms25010299 - 25 Dec 2023
Viewed by 990
Abstract
Type I interferon (IFN-I)-induced signaling plays a critical role in host antiviral innate immune responses. Despite this, the mechanisms that regulate this signaling pathway have yet to be fully elucidated. The nucleoporin Ran Binding Protein 2 (RanBP2) (also known as Nucleoporin 358 KDa, [...] Read more.
Type I interferon (IFN-I)-induced signaling plays a critical role in host antiviral innate immune responses. Despite this, the mechanisms that regulate this signaling pathway have yet to be fully elucidated. The nucleoporin Ran Binding Protein 2 (RanBP2) (also known as Nucleoporin 358 KDa, Nup358) has been implicated in a number of cellular processes, including host innate immune signaling pathways, and is known to influence viral infection. In this study, we documented that RanBP2 mediates the sumoylation of signal transducers and activators of transcription 1 (STAT1) and inhibits IFN-α-induced signaling. Specifically, we found that RanBP2-mediated sumoylation inhibits the interaction of STAT1 and Janus kinase 1 (JAK1), as well as the phosphorylation and nuclear accumulation of STAT1 after IFN-α stimulation, thereby antagonizing the IFN-α-mediated antiviral innate immune signaling pathway and promoting viral infection. Our findings not only provide insights into a novel function of RanBP2 in antiviral innate immunity but may also contribute to the development of new antiviral therapeutic strategies. Full article
(This article belongs to the Special Issue Recent Advances of Biochemistry and Molecular Biology of Infectious Diseases, 2nd Edition)
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Review

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24 pages, 498 KiB  
Review
Virulence Mechanisms of Staphylococcal Animal Pathogens
by Gordon Y. C. Cheung and Michael Otto
Int. J. Mol. Sci. 2023, 24(19), 14587; https://doi.org/10.3390/ijms241914587 - 26 Sep 2023
Cited by 2 | Viewed by 1331
Abstract
Staphylococci are major causes of infections in mammals. Mammals are colonized by diverse staphylococcal species, often with moderate to strong host specificity, and colonization is a common source of infection. Staphylococcal infections of animals not only are of major importance for animal well-being [...] Read more.
Staphylococci are major causes of infections in mammals. Mammals are colonized by diverse staphylococcal species, often with moderate to strong host specificity, and colonization is a common source of infection. Staphylococcal infections of animals not only are of major importance for animal well-being but have considerable economic consequences, such as in the case of staphylococcal mastitis, which costs billions of dollars annually. Furthermore, pet animals can be temporary carriers of strains infectious to humans. Moreover, antimicrobial resistance is a great concern in livestock infections, as there is considerable antibiotic overuse, and resistant strains can be transferred to humans. With the number of working antibiotics continuously becoming smaller due to the concomitant spread of resistant strains, alternative approaches, such as anti-virulence, are increasingly being investigated to treat staphylococcal infections. For this, understanding the virulence mechanisms of animal staphylococcal pathogens is crucial. While many virulence factors have similar functions in humans as animals, there are increasingly frequent reports of host-specific virulence factors and mechanisms. Furthermore, we are only beginning to understand virulence mechanisms in animal-specific staphylococcal pathogens. This review gives an overview of animal infections caused by staphylococci and our knowledge about the virulence mechanisms involved. Full article
(This article belongs to the Special Issue Recent Advances of Biochemistry and Molecular Biology of Infectious Diseases, 2nd Edition)
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