Molecular Advances in Osteoporosis Study

Dear Colleagues,

Osteoporosis is a bone disease that develops when bone mineral density and bone mass decrease, or when the structure and strength of bone change. This can lead to a decrease in bone strength, increasing the risk of fractures (broken bones). Testosterone, estrogen, SHBG, and FSH levels help to determine bone mass accrual, BMD maintenance, and lifetime decrease. Fractures are the most serious complication of osteoporosis and are responsible for the morbidity and mortality rates associated with the disease. Therefore, the establishment of risk scales or algorithms that help us to predict the risk of fracture is key to the establishment of the most efficient therapeutic measures. Currently, the most widely used tool is the FRAX, adapted to each country and sponsored by the WHO.

There is a parallel between osteoporosis and cardiovascular disease. Risk factors determine the occurrence of the different events that establish the severity of the disease. On the other hand, there are etiopathogenic elements common to both diseases that can help modify the risk of complications, justifying an analysis of the relationship between both processes. In particular, we welcome research studies covering novel signaling pathways and signaling molecules between both diseases.

This Special Issue aims to update research on signaling molecules and preclinical approaches to osteoporosis and overall fracture risk. Since IJMS is a journal of molecular science, purely clinical studies will not be suitable. However, clinical or pure model submissions with biomolecular experiments are welcomed.

Prof. Dr. José Luis P. Pérez-Castrillón
Dr. Ricardo Usategui-Martín
Guest Editors

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• osteoporosis
• fractures
• the pathogenesis of bone fragility
• cardiovascular disease
• molecular mechanisms
• signaling pathways