DNA Damage and DNA Repair Pathways in Cancer Development
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: closed (30 April 2024) | Viewed by 520
Special Issue Editor
Interests: transcription-coupled DNA damage; lymphomagenesis; mRNA export; breast carcinogenesis; antibody engineering
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
DNA lesions produced by a variety of genotoxic stresses are precisely repaired to avoid the genomic instability which is associated with a high predisposition to cancer development. The occurrence of unrepaired DNA lesions is censored by DNA-damage response (DDR) composed of complex cascades followed by the induction of cell-cycle arrest or apoptosis. As most tumors show impaired DDR, many studies have focused on the understanding of detailed molecular mechanisms in DDR-pathways and/or cancer-related DNA repair defects to reveal the cause of cancers. In addition, this information has provided us new therapeutic targets. Recently, when the germ-line mutations exist in breast cancers, PARP inhibitors offer a new therapeutic option based on the concept of synthetic lethality. Moreover, it is known that various inhibitors targeting molecules associated with DDR are in clinical trials. Comprehensive analyses of canonical and non-canonical DNA repair pathways and the interactions of each molecule defective in various cancers are promising to search for potential therapeutic targets. Therefore, authors are invited to submit original research and review articles that address the physiological, pathophysiological, pharmacological, and epidemiological importance of DDR and/or DNA repair pathways in cancer development.
Topics include, but are not limited to:
- Involvement of canonical or non-canonical DNA repair pathways in cancer development;
- Identification of the novel therapeutic targets in DNA repair pathway;
- Animal models mimicking the development of various human cancers;
- Pathological significance of aberrantly expressed DNA repair-related molecules in human clinical samples.
Dr. Kazuhiko Kuwahara
Guest Editor
Manuscript Submission Information
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Keywords
- DNA-damage response
- DNA repair molecules
- genome instability
- cellular senescence
- animal models
- DNA damage
- DNA repair and cancer
