International Journal of Molecular Sciences

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Special Issue Editors

Dr. Arnau Panisello-Roselló

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Guest Editor

Steatohepatitis and Transplantation Research Group, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Catalonia, Spain
Interests: pathophysiology of ischemia reperfusion injury; cell signaling molecular mechanisms; liver transplantation; dynamic preservation strategies (HOPE and NMP); inflammatory mediators; nitric oxide; DAMPS; inflammasome NLRP3; cytokines
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Dr. Emma Folch-Puy

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Guest Editor

Experimental Pathology Department, Institut d’Investigacions Biomèdiques de Barcelona (IIBB), Spanish National Research Council (CSIC)-IDIBAPS, CIBEREHD, 08036 Barcelona, Catalonia, Spain
Interests: inflammation; pancreatic adenocarcinoma; cell signalling; Reg3beta; immune response; Pancreatitis-Associated Protein (PAP); pancreas isquemia-reperfusion; preservation solutions; liver isquemia-reperfusion injury

Special Issue Information

Dear Colleagues,

"Hepatopancreatic and Intestine Diseases: From Molecular Basis to Therapy" is a Special Issue that delves deeply into the intricate molecular foundations and cutting-edge therapeutic strategies for the treatment of a broad spectrum of diseases affecting the hepatopancreatic system and intestine. The articles in this Special Issue provide profound insights into the complex molecular mechanisms driving these diseases and introduce innovative therapeutic approaches on a molecular level.

Encompassing a diverse range of hepatopancreatic and intestine diseases, such as disorders, viral diseases, inflammatory diseases, and cancers, these articles explore the intricate interplay of genetics, epigenetics, and environmental factors in the pathogenesis of these conditions. They shed light on the molecular pathways orchestrating disease development, unraveling the underlying mechanisms that contribute to their progression.

Moreover, this Special Issue offers a comprehensive overview of state-of-the-art diagnostic tools and treatment options that specifically target the molecular aspects of each disease entity. From pharmacological interventions and surgical techniques to immunotherapies, emerging targeted therapies, and regenerative medicine approaches, the articles in this Special Issue present a wealth of therapeutic possibilities grounded in molecular research.

By emphasizing the importance of interdisciplinary collaboration and personalized medicine, this Special Issue aims to advance the field of hepatopancreatic and intestine diseases at the molecular level, ultimately leading to enhanced patient outcomes. It serves as an invaluable resource for researchers, clinicians, and healthcare professionals dedicated to unraveling the molecular basis of these diseases and revolutionizing their management through molecularly targeted interventions.

Dr. Arnau Panisello-Roselló
Dr. Emma Folch-Puy
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

hepatopancreatic diseases
intestine diseases
molecular basis
therapy
pathogenesis
molecular pathways
pharmacological interventions
surgical techniques
immunotherapies
regenerative medicine approaches

Published Papers (2 papers)

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Research

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13 pages, 8634 KiB

Open AccessArticle

The Role of Hypoxia-Inducible Factor 1 Alpha in Acute-on-Chronic Liver Failure

by Marcus M. Mücke, Nihad El Bali, Katharina M. Schwarzkopf, Frank Erhard Uschner, Nico Kraus, Larissa Eberle, Victoria Therese Mücke, Julia Bein, Sandra Beyer, Peter J. Wild, Robert Schierwagen, Sabine Klein, Stefan Zeuzem, Christoph Welsch, Jonel Trebicka and Angela Brieger

Int. J. Mol. Sci. 2024, 25(3), 1542; https://doi.org/10.3390/ijms25031542 - 26 Jan 2024

Viewed by 945

Abstract

Acute-on-chronic liver failure (ACLF) is associated with increased mortality. Specific therapy options are limited. Hypoxia-inducible factor 1 alpha (HIF-1α) has been linked to the pathogenesis of chronic liver disease (CLD), but the role of HIF-1α in ACLF is poorly understood. In the current study, different etiologies of CLD and precipitating events triggering ACLF were used in four rodent models. HIF-1α expression and the intracellular pathway of HIF-1α induction were investigated using real-time quantitative PCR. The results were verified by Western blotting and immunohistochemistry for extrahepatic HIF-1α expression using transcriptome analysis. Exploratory immunohistochemical staining was performed to assess HIF-1α in human liver tissue. Intrahepatic HIF-1α expression was significantly increased in all animals with ACLF, regardless of the underlying etiology of CLD or the precipitating event. The induction of HIF-1α was accompanied by the increased mRNA expression of NFkB1 and STAT3 and resulted in a marked elevation of mRNA levels of its downstream genes. Extrahepatic HIF-1α expression was not elevated. In human liver tissue samples, HIF-1α expression was elevated in CLD and ACLF. Increased intrahepatic HIF-1α expression seems to play an important role in the pathogenesis of ACLF, and future studies are pending to investigate the role of therapeutic HIF inhibitors in ACLF. Full article

(This article belongs to the Special Issue Hepatopancreatic and Intestine Diseases: From Molecular Basis to Therapy)

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Review

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31 pages, 2025 KiB

Open AccessReview

Focusing on Ischemic Reperfusion Injury in the New Era of Dynamic Machine Perfusion in Liver Transplantation

by Gabriela Chullo, Arnau Panisello-Rosello, Noel Marquez, Jordi Colmenero, Merce Brunet, Miguel Pera, Joan Rosello-Catafau, Ramon Bataller, Juan Carlos García-Valdecasas and Yiliam Fundora

Int. J. Mol. Sci. 2024, 25(2), 1117; https://doi.org/10.3390/ijms25021117 - 17 Jan 2024

Cited by 2 | Viewed by 1138

Abstract

Liver transplantation is the most effective treatment for end-stage liver disease. Transplant indications have been progressively increasing, with a huge discrepancy between the supply and demand of optimal organs. In this context, the use of extended criteria donor grafts has gained importance, even though these grafts are more susceptible to ischemic reperfusion injury (IRI). Hepatic IRI is an inherent and inevitable consequence of all liver transplants; it involves ischemia-mediated cellular damage exacerbated upon reperfusion and its severity directly affects graft function and post-transplant complications. Strategies for organ preservation have been constantly improving since they first emerged. The current gold standard for preservation is perfusion solutions and static cold storage. However, novel approaches that allow extended preservation times, organ evaluation, and their treatment, which could increase the number of viable organs for transplantation, are currently under investigation. This review discusses the mechanisms associated with IRI, describes existing strategies for liver preservation, and emphasizes novel developments and challenges for effective organ preservation and optimization. Full article

(This article belongs to the Special Issue Hepatopancreatic and Intestine Diseases: From Molecular Basis to Therapy)

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