Molecular Mechanisms and Biomarkers for Appropriate Diagnosis and Therapeutic Strategy in Organ Dysfunction

Dear Colleagues,

Biomarkers reflecting, predicting, and associating pharmacological effects and/or toxicological disorders, as well as pathophysiological situations have been widely examined. Candidate molecules, as well as chemicals, that act as potential biomarkers for drug-induced organ toxicity have been discovered. Endogenous compounds are also well-applied in the clinical setting; however, some new chemicals, peptides, and miRNAs have been examined as new types of biomarkers. In the field of nephrotoxicity, serum creatinine is usually examined for use as a conventional marker of renal damage in clinical treatment. However, this biochemical parameter is acknowledged as being non-specific such that it can also be applied to drug-induced kidney injury. Similarly, drug-induced organ and/or cell injuries are often observed in pharmacotherapy and chemotherapy. Therefore, some organ-specific and/or drug-specific biological markers including functional proteins, peptides, nucleic acids, fatty acids, miRNAs, etc. are required to make accurate diagnoses and subsequent therapeutic strategies. These trends have been comparable with the development of several disease-specific biomarkers in various fields. Recently, the research area of biomarkers in pharmacology/toxicology and organ dysfunction has been expanded to find the physiological and pathophysiological significance in molecular-biological processes. With these exciting findings, this Special Issue focuses on “Molecular Mechanisms and Biomarkers for Appropriate Diagnosis and Therapeutic Strategy in Organ Dysfunction”.

Prof. Dr. Satohiro Masuda
Guest Editor

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• acute kidney injury
• chronic kidney disease
• liver injury
• cirrhosis
• lung injury
• neuropathy
• bone marrow injury
• cancer chemotherapy
• anti-infectious treatment
• immunosuppressive drugs
• anti-diabetic drugs
• cardiovascular disease
• inflammatory bowel disease
• autoimmune disease
• transplant immunology
• analytical methodology
• drug transporter
• drug metabolizing enzyme
• detoxification mechanism