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Molecular Mechanisms of the Pathogenesis of Antiphospholipid Syndrome (APS)
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Molecular Mechanisms of the Pathogenesis of Antiphospholipid Syndrome (APS)

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 30 June 2024 | Viewed by 2142

Special Issue Editor

Prof. Dr. Alexander Makatsariya

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Guest Editor
Vice-President of Russian Society of Obstetricians and Gynecologists, Academician of the Russian Academy of Sciences,The First I.M. Sechenov Moscow State Medical University, Moscow, Russia
Interests: thrombosis; thromboinflammation; disseminated intravascular coagulation syndrome; systemic inflammatory response syndrome; preeclampsia
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue will cover the problems of the mechanisms of thrombosis and thromboinflammation in general practice. These include septic complications, septic shock, obstetric problems associated with thromboinflammation in severe forms of pre-eclampsia, hemostatic disorders, and mechanisms of thrombosis and organ thrombotic disorders in patients with COVID-19 and post-COVID-19 neonatal sepsis as well as neonatal septic shock. 

Prof. Dr. Alexander Makatsariya
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • thrombosis
  • thromboinflammation
  • disseminated intravascular coagulation syndrome
  • systemic inflammatory response syndrome
  • thrombotic microangiopathy
  • pre-eclampsia
  • sepsis
  • septic shock

Published Papers (1 paper)

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Review

21 pages, 4095 KiB  
Review
Catastrophic Antiphospholipid Syndrome
by Victoria Bitsadze, Fidan Yakubova, Jamilya Khizroeva, Arina Lazarchuk, Polina Salnikova, Alexander Vorobev, Maria Tretyakova, Natalia Degtyareva, Kristina Grigoreva, Nilufar Gashimova, Margaret Kvaratskheliia, Nataliya Makatsariya, Ekaterina Kudryavtseva, Anna Tomlenova, Jean-Christophe Gris, Ismail Elalamy, Cihan Ay and Alexander Makatsariya
Int. J. Mol. Sci. 2024, 25(1), 668; https://doi.org/10.3390/ijms25010668 - 04 Jan 2024
Cited by 1 | Viewed by 1894
Abstract
Unlike classic APS, CAPS causes multiple microthrombosis due to an increased inflammatory response, known as a “thrombotic storm”. CAPS typically develops after infection, trauma, or surgery and begins with the following symptoms: fever, thrombocytopenia, muscle weakness, visual and cognitive disturbances, abdominal pain, renal [...] Read more.
Unlike classic APS, CAPS causes multiple microthrombosis due to an increased inflammatory response, known as a “thrombotic storm”. CAPS typically develops after infection, trauma, or surgery and begins with the following symptoms: fever, thrombocytopenia, muscle weakness, visual and cognitive disturbances, abdominal pain, renal failure, and disseminated intravascular coagulation. Although the presence of antiphospholipid antibodies in the blood is one of the diagnostic criteria, the level of these antibodies can fluctuate significantly, which complicates the diagnostic process and can lead to erroneous interpretation of rapidly developing symptoms. Triple therapy is often used to treat CAPS, which includes the use of anticoagulants, plasmapheresis, and high doses of glucocorticosteroids and, in some cases, additional intravenous immunoglobulins. The use of LMWH is recommended as the drug of choice due to its anti-inflammatory and anticoagulant properties. CAPS is a multifactorial disease that requires not only an interdisciplinary approach but also highly qualified medical care, adequate and timely diagnosis, and appropriate prevention in the context of relapse or occurrence of the disease. Improved new clinical protocols and education of medical personnel regarding CAPS can significantly improve the therapeutic approach and reduce mortality rates. Full article
(This article belongs to the Special Issue Molecular Mechanisms of the Pathogenesis of Antiphospholipid Syndrome (APS))
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