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Bioactive Lipids and Their Derivatives in Biomedical Applications
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Bioactive Lipids and Their Derivatives in Biomedical Applications

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 30 June 2024 | Viewed by 3717

Special Issue Editor

Dr. Marcelo Einicker-Lamas

E-Mail Website
Guest Editor
Laboratório de Biomembranas, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Ilha do Fundão, Rio de Janeiro 21941-902, Brazil
Interests: bioactive lipids; cell signaling; membrane receptors; cell physiology

Special Issue Information

Dear Colleagues,

Lipids and their derivatives are related to cell metabolism—energy stores—and cell protection, constituting biological membranes. This class of biological molecules is currently in the spotlight for either physiological or pathophysiological reasons due to their broad action in triggering different cell signaling pathways through the activation of specific membrane or intracellular receptors, or simply by changing membrane physical chemistry upon their occurrence.

Despite their status as a powerful class of modulators in different cell types, tissues, and organs, there is still little knowledge available regarding their potential as drug targets, agonists, or antagonists, and the repertoire of biomedical applications.

For these reasons, the aim of this Special Issue is to collect reports regarding all the recent approaches directed at the use of bioactive lipids, including glycerolipids, sphingolipids, fatty acids, prostaglandins, leukotrienes, endocannabinoids, and all the possible bioactive lipids for medicinal chemistry, pharmacology, molecular biology, lipidomics, drug development, and drug delivery studies. Other possibilities will be evaluated by the Editorial Board. We will consider the following formats: original research, reviews, opinion papers, or short communications.

The goal of this Special Issue is to provide a representative and topical overview of bioactive lipid studies and perspectives on biomedical applications. We look forward to your submissions.

Dr. Marcelo Einicker-Lamas
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bioactive lipids
  • phospholipids
  • sphingolipids
  • signaling
  • prostanoids
  • fatty acids
  • endocannabinoids
  • cholesterol
  • cell membrane
  • receptors

Published Papers (2 papers)

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Research

15 pages, 8226 KiB  
Article
Modulation of Dietary Choline Uptake in a Mouse Model of Acid Sphingomyelinase Deficiency
by Ángel Gaudioso, Pilar Moreno-Huguet, Josefina Casas, Edward H. Schuchman and María Dolores Ledesma
Int. J. Mol. Sci. 2023, 24(11), 9756; https://doi.org/10.3390/ijms24119756 - 05 Jun 2023
Viewed by 1421
Abstract
Acid sphingomyelinase deficiency (ASMD) is a lysosomal storage disorder caused by mutations in the gene-encoding acid sphingomyelinase (ASM). ASMD impacts peripheral organs in all patients, including the liver and spleen. The infantile and chronic neurovisceral forms of the disease also lead to neuroinflammation [...] Read more.
Acid sphingomyelinase deficiency (ASMD) is a lysosomal storage disorder caused by mutations in the gene-encoding acid sphingomyelinase (ASM). ASMD impacts peripheral organs in all patients, including the liver and spleen. The infantile and chronic neurovisceral forms of the disease also lead to neuroinflammation and neurodegeneration for which there is no effective treatment. Cellular accumulation of sphingomyelin (SM) is a pathological hallmark in all tissues. SM is the only sphingolipid comprised of a phosphocholine group linked to ceramide. Choline is an essential nutrient that must be obtained from the diet and its deficiency promotes fatty liver disease in a process dependent on ASM activity. We thus hypothesized that choline deprivation could reduce SM production and have beneficial effects in ASMD. Using acid sphingomyelinase knock-out (ASMko) mice, which mimic neurovisceral ASMD, we have assessed the safety of a choline-free diet and its effects on liver and brain pathological features such as altered sphingolipid and glycerophospholipid composition, inflammation and neurodegeneration. We found that the choline-free diet was safe in our experimental conditions and reduced activation of macrophages and microglia in the liver and brain, respectively. However, there was no significant impact on sphingolipid levels and neurodegeneration was not prevented, arguing against the potential of this nutritional strategy to assist in the management of neurovisceral ASMD patients. Full article
(This article belongs to the Special Issue Bioactive Lipids and Their Derivatives in Biomedical Applications)
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24 pages, 12690 KiB  
Article
Quantification of Giant Unilamellar Vesicle Fusion Products by High-Throughput Image Analysis
by Adriano Caliari, Martin M. Hanczyc, Masayuki Imai, Jian Xu and Tetsuya Yomo
Int. J. Mol. Sci. 2023, 24(9), 8241; https://doi.org/10.3390/ijms24098241 - 04 May 2023
Cited by 1 | Viewed by 1736
Abstract
Artificial cells are based on dynamic compartmentalized systems. Thus, remodeling of membrane-bound systems, such as giant unilamellar vesicles, is finding applications beyond biological studies, to engineer cell-mimicking structures. Giant unilamellar vesicle fusion is rapidly becoming an essential experimental step as artificial cells gain [...] Read more.
Artificial cells are based on dynamic compartmentalized systems. Thus, remodeling of membrane-bound systems, such as giant unilamellar vesicles, is finding applications beyond biological studies, to engineer cell-mimicking structures. Giant unilamellar vesicle fusion is rapidly becoming an essential experimental step as artificial cells gain prominence in synthetic biology. Several techniques have been developed to accomplish this step, with varying efficiency and selectivity. To date, characterization of vesicle fusion has relied on small samples of giant vesicles, examined either manually or by fluorometric assays on suspensions of small and large unilamellar vesicles. Automation of the detection and characterization of fusion products is now necessary for the screening and optimization of these fusion protocols. To this end, we implemented a fusion assay based on fluorophore colocalization on the membranes and in the lumen of vesicles. Fluorescence colocalization was evaluated within single compartments by image segmentation with minimal user input, allowing the application of the technique to high-throughput screenings. After detection, statistical information on vesicle fluorescence and morphological properties can be summarized and visualized, assessing lipid and content transfer for each object by the correlation coefficient of different fluorescence channels. Using this tool, we report and characterize the unexpected fusogenic activity of sodium chloride on phosphatidylcholine giant vesicles. Lipid transfer in most of the vesicles could be detected after 20 h of incubation, while content exchange only occurred with additional stimuli in around 8% of vesicles. Full article
(This article belongs to the Special Issue Bioactive Lipids and Their Derivatives in Biomedical Applications)
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