New Trends in Molecular Biosensors

Dear Colleagues,

Biosensors applied for the investigation of biomolecular interactions are still at the initial stage of development, and their successful development requires in-depth studies of both reaction kinetics and mechanisms of transduction. The large majority of previous research focused on applications in the fields of cancer and genomic research for the detection of disease biomarkers and genetic mutations.

Among the analytical techniques that are suitable for the quantification of the thermodynamic constants of binding are: systems based on mechanical and viscoelastic properties (functionalized cantilevers), optical-based biosensors with different schemes of exciting radiation and recording (plasmonic, fluorescence-based, coupled evanescent field), electrochemical devices with a discrete number of electrical protocols in continuous and alternate currents, electronic transducers, such as silicon nanowire transistors, organic semiconductors or conductive polymer-based transistors.

Lipid membranes constitute one of the main supporting systems for bioreceptor proteins in living organisms. Most of the reactions taking place during the recognition events reflect the exquisite selectivity and sensibility of the bioreceptor for particular analytes, and the complexity of the multicomponent environment that modifies the affinity of the inserted protein. Biosensors with integrated functional membranes mimicking the performances of bioreceptors are still in their infancy, and thus require extensive investigation.

Dr. Pierpaolo Greco
Dr. Giorgio Rispoli
Guest Editors

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• SPR biosensors
• electrochemical biosensors
• cantilever based biosensors
• organic electronic based biosensors
• lipid membranes

• Molecular Biosensor in International Journal of Molecular Sciences (7 articles)