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Molecular Biology of Disease Vectors Volume 2
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Molecular Biology of Disease Vectors Volume 2

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: closed (30 June 2023) | Viewed by 4790

Special Issue Editor

Dr. Michail Kotsyfakis

E-Mail Website1 Website2
Guest Editor
Institute of Parasitology, Biology Center of the Czech Academy of Sciences, 37005 Budweis (Ceske Budejovice), Czech Republic
Interests: biology of disease vectors; ectoparasite/host interaction; protease inhibitors; cystatin; arthropod; transcriptomics; proteomics; arthropod saliva; immunomodulation; hemostasis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Arthropod disease vectors transmit not only serious diseases such as malaria, but numerous other diseases as well, many of which are neglected to various extents. In most cases, a tripartite interaction is involved between the arthropod disease vector, the vertebrate host, and the vector-borne pathogens. The aim of this Special issue is to collect the latest data (and up-to-date information in the case of reviews) about the molecular and biochemical events that mediate this tripartite interaction. The contribution of data (coming, for example, from systems biology and molecular biology/biochemical approaches or reviews) is anticipated to improve our knowledge of the biology of any of the three key partners involved in vector-borne disease transmission and/or of their intimate interactions. Specific subtopics of interest in this Special Issue include but are not limited to the following: disease vector–vertebrate host interactions, vector-borne pathogen interactions with the disease vector and the vertebrate host, molecular biology/microbiology of arthropod-borne pathogens, vertebrate host response to arthropod-borne pathogens, and molecular biology of disease vectors (e.g., arthropod immunity, blood meal digestion, oogenesis/reproduction, olfaction and other sensory cues, and insecticide resistance).

Dr. Michail Kotsyfakis
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • disease vector biology
  • arthropod
  • vector-borne disease
  • hematophagy
  • immune response to vector-borne pathogens
  • arthropod immunity
  • disease vector–pathogen interaction
  • disease vector–vertebrate host interactions
  • disease transmission
  • disease vector development
  • insecticide resistance

Published Papers (2 papers)

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Research

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18 pages, 3203 KiB  
Article
Protein Profiling of Aedes aegypti Treated with Streptomyces sp. KSF103 Ethyl Acetate Extract Reveals Potential Insecticidal Targets and Metabolic Pathways
by Ker Shien Tan, Adzzie Shazleen Azman, Pouya Hassandarvish, Zheng Hua Amelia-Yap, Tiong Kai Tan and Van Lun Low
Int. J. Mol. Sci. 2023, 24(15), 12398; https://doi.org/10.3390/ijms241512398 - 3 Aug 2023
Cited by 1 | Viewed by 1437
Abstract
The insecticidal activity of Streptomyces sp. KSF103 ethyl acetate (EA) extract against mosquitoes is known; however, the underlying mechanism behind this activity remains elusive. In this study, liquid chromatography with tandem mass spectrometry (LC-MS/MS) was employed to investigate changes in the protein profile [...] Read more.
The insecticidal activity of Streptomyces sp. KSF103 ethyl acetate (EA) extract against mosquitoes is known; however, the underlying mechanism behind this activity remains elusive. In this study, liquid chromatography with tandem mass spectrometry (LC-MS/MS) was employed to investigate changes in the protein profile of Aedes aegypti larvae and adults treated with lethal concentrations of 50 (LC50) EA extract. By comparing the treated and untreated mosquitoes, this study aimed to identify proteins or pathways that exhibit alterations, potentially serving as targets for future insecticide development. Treatment with a lethal concentration of EA extract upregulated 15 proteins in larvae, while in adults, 16 proteins were upregulated, and two proteins were downregulated. These proteins were associated with metabolism, protein regulation/degradation, energy production, cellular organization and structure, enzyme activity, and catalysis, as well as calcium ion transport and homeostasis. Notably, ATP synthase, fructose-bisphosphate aldolase (FBA), and ATP citrate synthase were significantly expressed in both groups. Gene ontology analysis indicated a focus on energy metabolic processes. Molecular docking revealed a strong interaction between dodemorph, selagine (compounds from the EA extract), and FBA, suggesting FBA as a potential protein target for insecticide development. Further studies such as Western blot and transcriptomic analyses are warranted to validate the findings. Full article
(This article belongs to the Special Issue Molecular Biology of Disease Vectors Volume 2)
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Review

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25 pages, 903 KiB  
Review
Recent Advances in Tick Antigen Discovery and Anti-Tick Vaccine Development
by Muhammad Nadeem Abbas, Mohamed Amine Jmel, Imen Mekki, Ingrid Dijkgraaf and Michail Kotsyfakis
Int. J. Mol. Sci. 2023, 24(5), 4969; https://doi.org/10.3390/ijms24054969 - 4 Mar 2023
Cited by 13 | Viewed by 3044
Abstract
Ticks can seriously affect human and animal health around the globe, causing significant economic losses each year. Chemical acaricides are widely used to control ticks, which negatively impact the environment and result in the emergence of acaricide-resistant tick populations. A vaccine is considered [...] Read more.
Ticks can seriously affect human and animal health around the globe, causing significant economic losses each year. Chemical acaricides are widely used to control ticks, which negatively impact the environment and result in the emergence of acaricide-resistant tick populations. A vaccine is considered as one of the best alternative approaches to control ticks and tick-borne diseases, as it is less expensive and more effective than chemical controls. Many antigen-based vaccines have been developed as a result of current advances in transcriptomics, genomics, and proteomic techniques. A few of these (e.g., Gavac® and TickGARD®) are commercially available and are commonly used in different countries. Furthermore, a significant number of novel antigens are being investigated with the perspective of developing new anti-tick vaccines. However, more research is required to develop new and more efficient antigen-based vaccines, including on assessing the efficiency of various epitopes against different tick species to confirm their cross-reactivity and their high immunogenicity. In this review, we discuss the recent advancements in the development of antigen-based vaccines (traditional and RNA-based) and provide a brief overview of recent discoveries of novel antigens, along with their sources, characteristics, and the methods used to test their efficiency. Full article
(This article belongs to the Special Issue Molecular Biology of Disease Vectors Volume 2)
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