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Micro/Nanofluidics: Novel Bioanalytical Technology

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 30 June 2024 | Viewed by 1252

Special Issue Editor


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Guest Editor
Faculty of Pharmacy, Institute of Biomedical Engineering, University of Toronto, Toronto, ON M5S 3G9, Canada
Interests: biofabrication; biomicrofluidics; biointerface; cell therapy; precision medicine; mechanobiology; stem cells; regenerative medicine
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Special Issue Information

Dear Colleagues,

Micro/nanofluidics has emerged as a highly promising field that enables the precise manipulation and control of fluids, cells, and molecules at the micro- and nanoscale. It offers unprecedented opportunities for the development of innovative techniques and devices that may revolutionize the field of bioanalytical technology, especially for the decentralized and rapid detection of pathogens and infections.

We are pleased to announce a call for papers for a Special Issue entitled "Micro/Nanofluidics: Novel Bioanalytical Technology", which is to be published in the International Journal of Molecular Sciences. This Special Issue aims to provide a platform for researchers and scientists to present their cutting-edge research and highlight recent advancements in this field, exploring novel concepts, materials, methodologies, translations, and validations of micro/nanofluidics in various bioanalytical applications.

We invite researchers from academia, industry, and other related fields to submit original research and review articles that address various aspects of micro/nanofluidics in bioanalytical technology. The topics of interest include, but are not limited to, the following:

  • Miniaturized physical sensors;
  • Miniaturized chemical sensors;
  • Miniaturized biosensors;
  • Flexible and wearable sensors;
  • Computational modeling of sensors;
  • Discovery of affinity reagents (aptamers, antibodies, enzymes, etc.);
  • New sensing mechanisms and materials;
  • Clinical translation and field validation of bioanalytical systems.

Dr. Zongjie Wang
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • microfluidics
  • nanofluidics
  • analytical chemistry
  • material chemistry
  • biosensor
  • chemsensor
  • diagnostics

Published Papers (1 paper)

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Research

12 pages, 2890 KiB  
Article
A Surface-Enhanced Raman Spectroscopy-Based Biosensor for the Detection of Biological Macromolecules: The Case of the Lipopolysaccharide Endotoxin Molecules
by Giulia Rusciano, Angela Capaccio, Antonio Sasso, Alessandro Capo, Carlos Murillo Almuzara, Maria Staiano, Sabato D’Auria and Antonio Varriale
Int. J. Mol. Sci. 2023, 24(15), 12099; https://doi.org/10.3390/ijms241512099 - 28 Jul 2023
Cited by 2 | Viewed by 1031
Abstract
The development of sensitive methods for the detection of endotoxin molecules, such as lipopolysaccharides (LPS), is essential for food safety and health control. Conventional analytical methods used for LPS detection are based on the pyrogen test, plating and culture-based methods, and the limulus [...] Read more.
The development of sensitive methods for the detection of endotoxin molecules, such as lipopolysaccharides (LPS), is essential for food safety and health control. Conventional analytical methods used for LPS detection are based on the pyrogen test, plating and culture-based methods, and the limulus amoebocyte lysate method (LAL). Alternatively, the development of reliable biosensors for LPS detection would be highly desirable to solve some critical issues, such as high cost and a long turnaround time. In this work, we present a label-free Surface-Enhanced Raman Spectroscopy (SERS)-based method for LPS detection in its free form. The proposed method combines the benefits of plasmonic enhancement with the selectivity provided by a specific anti-lipid A antibody (Ab). A high-enhancing nanostructured silver substrate was coated with Ab. The presence of LPS was quantitatively monitored by analyzing the changes in the Ab spectra obtained in the absence and presence of LPS. A limit of detection (LOD) and quantification (LOQ) of 12 ng/mL and 41 ng/mL were estimated, respectively. Importantly, the proposed technology could be easily expanded for the determination of other biological macromolecules. Full article
(This article belongs to the Special Issue Micro/Nanofluidics: Novel Bioanalytical Technology)
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