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Genetics and Molecular Mechanisms in Psychological and Neuropsychiatric Disorders

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".

Deadline for manuscript submissions: closed (29 February 2024) | Viewed by 957

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Department of Pharmaceutical Science, University of Perugia, 06100 Perugia, Italy
Interests: lipid metabolism; nuclear lipids; cancer; cell proliferation and differentiation; neurodegenerative disorders; liver; brain; thyroid
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Special Issue Information

Dear Colleagues,

In the last decade, the exponential increase in genetic studies has significantly advanced the knowledge of both psychological and neuropsychiatric brain pathologies. Recent research has demonstrated the prevalence of Alzheimer's disease, Parkinson's disease, epilepsy, mood disorders, etc. in different populations and/or in relation to sex. Interestingly, many researchers are turning their attention to the molecular implications of genetic modification. This Special Issue welcomes the submission of original research papers or comprehensive reviews that demonstrate or summarize significant advances in the field of genetics in the pathogenesis of psychological, neurological and psychiatric disorders. Basic research studies and/or clinical studies accompanied by experimental data will be considered.

Prof. Dr. Elisabetta Albi
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

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Keywords

  • psychological disorder
  • neurological disorders
  • psychiatric disorders
  • genetics lipids

Published Papers (1 paper)

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Review

16 pages, 4779 KiB  
Review
Genetic Update and Treatment for Dystonia
by Jan Koptielow, Emilia Szyłak, Olga Szewczyk-Roszczenko, Piotr Roszczenko, Jan Kochanowicz, Alina Kułakowska and Monika Chorąży
Int. J. Mol. Sci. 2024, 25(7), 3571; https://doi.org/10.3390/ijms25073571 - 22 Mar 2024
Viewed by 634
Abstract
A neurological condition called dystonia results in abnormal, uncontrollable postures or movements because of sporadic or continuous muscular spasms. Several varieties of dystonia can impact people of all ages, leading to severe impairment and a decreased standard of living. The discovery of genes [...] Read more.
A neurological condition called dystonia results in abnormal, uncontrollable postures or movements because of sporadic or continuous muscular spasms. Several varieties of dystonia can impact people of all ages, leading to severe impairment and a decreased standard of living. The discovery of genes causing variations of single or mixed dystonia has improved our understanding of the disease’s etiology. Genetic dystonias are linked to several genes, including pathogenic variations of VPS16, TOR1A, THAP1, GNAL, and ANO3. Diagnosis of dystonia is primarily based on clinical symptoms, which can be challenging due to overlapping symptoms with other neurological conditions, such as Parkinson’s disease. This review aims to summarize recent advances in the genetic origins and management of focal dystonia. Full article
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