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IJMS
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Predictive and Diagnostic Biomarkers in Inflammatory and Neurodegenerative Diseases
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Predictive and Diagnostic Biomarkers in Inflammatory and Neurodegenerative Diseases

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".

Deadline for manuscript submissions: 31 August 2024 | Viewed by 388

Special Issue Editor

Dr. Maria Morello

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Guest Editor
Clinical Biochemistry and Molecular Biology, Faculty of Medicine, Department of Experimental Medicine, University Hospital of Tor Vergata (PTV), University of Rome Tor Vergata, Rome, Italy
Interests: clinical biochemistry; COVID; nutrition; vitamins; inflammation; neuroscience; neurodegenerative diseases; CSF indexes; blood morphology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Several neurodegenerative pathologies of the nervous system, such as Alzheimer’s disease (AD), Parkinson’s disease (PD), multiple sclerosis (MS) and amyotrophic lateral sclerosis (ALS), share a common state of chronic neuroinflammation. This Special Issue presents a collection of research articles and reviews investigating the molecular and cellular mechanisms underlying neurodegeneration. The focus is on studying the diagnostic performance of inflammation biomarkers and pathology-specific biological indicators (both classic and new-generation biomarkers) to identify reliable biomarkers that can guide future research and emphasize their utility in clinical practice.

Dr. Maria Morello
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Parkinson’s disease
  • Alzheimer’s disease
  • multiple sclerosis
  • amyotrophic lateral sclerosis
  • neurodegenerative diseases
  • inflammation amyloid plaques
  • tau
  • alpha-synuclein
  • cytokines
  • neurofilaments
  • vitamins

Published Papers (1 paper)

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Review

23 pages, 1424 KiB  
Review
Laboratory Diagnosis of Intrathecal Synthesis of Immunoglobulins: A Review about the Contribution of OCBs and K-index
by Maria Morello, Simone Mastrogiovanni, Fabio Falcione, Vanessa Rossi, Sergio Bernardini, Stefania Casciani, Antonietta Viola, Marilina Reali and Massimo Pieri
Int. J. Mol. Sci. 2024, 25(10), 5170; https://doi.org/10.3390/ijms25105170 - 9 May 2024
Viewed by 261
Abstract
The diagnosis of MS relies on a combination of imaging, clinical examinations, and biological analyses, including blood and cerebrospinal fluid (CSF) assessments. G-Oligoclonal bands (OCBs) are considered a “gold standard” for MS diagnosis due to their high sensitivity and specificity. Recent advancements have [...] Read more.
The diagnosis of MS relies on a combination of imaging, clinical examinations, and biological analyses, including blood and cerebrospinal fluid (CSF) assessments. G-Oligoclonal bands (OCBs) are considered a “gold standard” for MS diagnosis due to their high sensitivity and specificity. Recent advancements have involved the introduced of kappa free light chain (k-FLC) assay into cerebrospinal fluid (CSF) and serum (S), along with the albumin quotient, leading to the development of a novel biomarker known as the “K-index” or “k-FLC index”. The use of the K-index has been recommended to decrease costs, increase laboratory efficiency, and to skip potential subjective operator-dependent risk that could happen during the identification of OCBs profiles. This review aims to provide a comprehensive overview and analysis of recent scientific articles, focusing on updated methods for MS diagnosis with an emphasis on the utility of the K-index. Numerous studies indicate that the K-index demonstrates high sensitivity and specificity, often comparable to or surpassing the diagnostic accuracy of OCBs evaluation. The integration of the measure of the K-index with OCBs assessment emerges as a more precise method for MS diagnosis. This combined approach not only enhances diagnostic accuracy, but also offers a more efficient and cost-effective alternative. Full article
(This article belongs to the Special Issue Predictive and Diagnostic Biomarkers in Inflammatory and Neurodegenerative Diseases)
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