Pharmacological Approaches and Models of Physical Activity in the Treatment of Inflammatory Diseases and Cancer

Dear Colleagues,

Cancer encompasses a complex array of molecular and cellular changes that trigger abnormal cell growth and uncontrolled proliferation. Its development involves a combination of genetic, immunological, and metabolic alterations, all of which contribute to oncogenesis and tumor progression. While conventional treatments like chemotherapy, radiotherapy, surgery, and drug therapies remain essential, there is growing recognition of the value of lifestyle interventions for improving clinical outcomes.

Various activity models designed to alleviate stressors have been advocated for as part of cancer management. Research suggests that sedentary behavior and exposure to unfavorable environmental conditions can lead to physiological imbalances such as chronic inflammation and oxidative stress, resulting in the development of chronic diseases and premature mortality. Conversely, regular engagement in both aerobic and anaerobic physical activities offers numerous health benefits, including weight control, increased fat-free mass, enhanced bone mineral density, and improved cardiorespiratory fitness.

Furthermore, disruptions to these components have been linked to the onset of chronic degenerative conditions, including inflammatory diseases and different types of cancer. At the molecular and cellular levels, evidence suggests that physical activity can modulate signaling pathways involved in key processes implicated in cancer pathophysiology, such as the inflammatory response, mitochondrial dysfunction, endoplasmic and oxidative reticulum stress, and autophagy.

Thus, it becomes evident that understanding the impacts of diverse pharmacological strategies and various models of physical activity is crucial in the comprehensive treatment and rehabilitation of inflammatory diseases and cancer. By integrating both pharmacological interventions and tailored exercise regimens, healthcare professionals can optimize patient outcomes and enhance the overall effectiveness of therapeutic approaches.

This Special Issue of the International Journal of Molecular Sciences (IJMS) focuses on the “Pharmacological Approaches and Models of Physical Activity in the Treatment of Inflammatory Diseases and Cancer”, and welcomes both original research articles and review papers.

Dr. Fabricio Oliveira Souto
Guest Editor

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• physical exercise
• drugs
• cytokines
• inflammation
• oncology