ijms-logo

Journal Browser

Journal Browser

Molecular Mechanisms of Tendinopathy: Unraveling the Pathogenesis of Tendon Diseases

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 31 August 2024 | Viewed by 593

Special Issue Editor


E-Mail Website
Guest Editor
Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Hong Kong SAR, China
Interests: tendinopathy; tendon stem cells and their niches; tissue engineering and regenerative medicine; tendon and ligament healing

Special Issue Information

Dear Colleagues,

Tendinopathy is a multi-factorial tendon and joint disorder characterized by activity-related tendon pain, stiffness, and physical disability. The affected tendon degenerates and finally ruptures. Both conservative and surgical outcomes are unsatisfactory due to its unclear etiopathogenesis.

This Special Issue aims to encourage the study of the molecular mechanisms of tendinopathy and identify novel targets for its management. Both review and original articles focusing on the risk factors, molecular mechanisms, and novel treatment of tendinopathy are welcome. The roles of various risk factors, such as diabetes mellitus, obesity, dyslipidemia, and drugs, in increasing the susceptibility of tendinopathy development are of particular interest in this Special Issue. Factors affecting healing outcomes after tendon reattachment to bone and tendon repair after injury are within the scope of this Special Issue.

Studies on advanced molecular tools, such as various omics techniques, animal models, and new treatments, including cell-based therapy, drugs and biophysical therapies, and novel biomaterials, are encouraged to be submitted to this Special Issue.

Dr. Pauline Po Yee Lui 
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • tendinopathy
  • tendon pain
  • stiffness
  • physical disability
  • etiopathogenesis
  • molecular mechanisms
  • tendon reattachment
  • tendon repair
  • advanced molecular tools
  • omics techniques
  • biophysical therapies
  • novel biomaterials

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

14 pages, 5145 KiB  
Article
Establishment of a Mouse Degenerative Model of Patellar Tendinopathy with Upregulation of Inflammation
by Pauline Po Yee Lui, Zuru Liang, Ri Min Tan and Patrick Shu Hang Yung
Int. J. Mol. Sci. 2024, 25(7), 3847; https://doi.org/10.3390/ijms25073847 - 29 Mar 2024
Viewed by 437
Abstract
There is no mouse model of patellar tendinopathy. This study aimed to establish a mouse inflammatory and degenerative patellar tendon injury model, which will facilitate research on patellar tendinopathy using advanced molecular tools including transgenic models. Collagenase at different doses (low dose (LD), [...] Read more.
There is no mouse model of patellar tendinopathy. This study aimed to establish a mouse inflammatory and degenerative patellar tendon injury model, which will facilitate research on patellar tendinopathy using advanced molecular tools including transgenic models. Collagenase at different doses (low dose (LD), medium dose (MD), high dose (HD)) or saline was injected over the mouse patellar tendon. At weeks 1, 2, 4, and 8 post-injection, the tendons were harvested for histology and further examined by micro-computed tomography (microCT) imaging at week 8. The optimal dose group and the saline group were further evaluated by immunohistochemical staining, gait pattern, and biomechanical properties. The histopathological score increased dose-dependently post-collagenase injection. Ectopic mineralization was observed and increased with collagenase dose. The LD group was selected for further analysis. The expression of IL-10, TNF-α, and MMP-1 significantly increased post-injection. The changes of limb idleness index (ΔLII) compared to preinjury state were significantly higher, while the ultimate load, stiffness, ultimate stress, and maximum Young’s modulus were significantly lower in the LD group compared to the saline group. A mouse inflammatory degenerative model of patellar tendon injury resembling tendinopathy was established as indicated by the dose-dependent increase in tendon histopathology, ectopic calcification, decrease in biomechanical properties, and pain-associated gait changes. Full article
Show Figures

Figure 1

Back to TopTop