Role of Drosophila in Human Disease Research 4.0
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 30 June 2024 | Viewed by 3115
Special Issue Editors
Interests: Drosophila model for human disease; epigenetics; DNA replication gene; autism spectrum disorder
Special Issues, Collections and Topics in MDPI journals
Interests: Drosophila models
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
For over a century, Drosophila melanogaster has been widely used in classical and modern genetics. Many biological functions are highly conserved between humans and Drosophila, and nearly 85% of human-disease-causing genes have functional homologues in Drosophila. Because of this, Drosophila has been used as a highly tractable animal model for studying human diseases, with notable success in the study of various neurodegenerative diseases, metabolic syndromes, and cancer. The similarities between the mammalian and Drosophila systems have also allowed Drosophila to play a role in the evaluation of candidate substances for the treatment of these human diseases.
More recently, based on similarities in the pathways involved in DNA replication, DNA repair pathways, physical and neurological properties, Drosophila models have also started to be used to study more complex psychiatric disorders, aging, and other rare intractable human genetic diseases. However, it is always important to keep in mind both the benefits and limitations of fly models by comparing them to other animal models, such as mouse, zebra fish, and nematode worm. For this Special Issue, we welcome original research and up-to-date review articles that provide novel insights into how Drosophila models (especially models of DNA replication and repair genes) have progressed the understanding of human disease.
Dr. Masamitsu Yamaguchi
Dr. Sue Cotterill
Guest Editors
Manuscript Submission Information
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Keywords
- Drosophila melanogaster
- human disease model
- cancer
- neurodegeneration
- psychiatric disorder
- mental retardation
- metabolic syndrome
- infectious disease
- aging
- epigenetic dysregulation
- mitochondrial disorder
- DNA replication or repair defects
