Molecular Mechanisms of Diabetes Genetics

Dear Colleagues,

Diabetes mellitus encompasses a heterogeneous group of disorders characterized by chronic hyperglycemia. Genetics plays a role to some extent in type 1 and type 2 diabetes. However, in rare forms, such as MODY and syndromic diabetes, genetics plays a pivotal role. Genetics does not play a role in the management or prevention of type 1 and type 2 diabetes, but it may allow researchers to design intervention trials and to identify patients at risk. Genetic testing could unravel the individual susceptibilities and drive the choice to reduce the risks by applying medical surveillance, lifestyle modifications or even drug therapy. In rare forms, early diagnosis by genetic testing may help to reduce the likelihood of long-term complications and assist in choosing the most appropriate treatment. Furthermore, psychological and family adjustments to diabetes may also be improved when the specific form of the disease is known. This Special Issue focuses on high-quality research papers that address genetic issues in every form of diabetes mellitus. Contributions from a wide range of professions are welcome. Specifically, we intend to promote original research papers, case report and state-of-the-art reviews. 

Dr. Maurizio Delvecchio
Guest Editor

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• MODY
• monogenic diabetes
• syndromic diabetes
• Wolfram syndrome
• mitocondrial diabetes
• predisposition to type 1 diabetes
• predisposition to type 2 diabetes
• precision medicine