Atherosclerosis: From Molecular Basis to Therapy

Dear Colleagues,

Atherosclerosis is a fibroproliferative disease that proceeds through a series of pathological events involving the inflammatory and immune systems as well as the different types of cells and matrix proteins of the vascular wall. The disease is accompanied by the subendothelial accumulation of lipids and fibrous connective tissue, the phenotypic modulation of SMCs, and the migration of a group of cells, notably monocytes and T cells, through the vascular endothelium in response to inflammation. In addition to well-known factors (e.g., high blood pressure, dyslipidemia, diabetes, excess body weight), there are several emerging factors associated with atherosclerosis such as inflammation, endothelial dysfunction, intestinal microbiota alteration, uric acid, vitamin D, or miRNA expression that could potentially explain the residual cardiovascular risk. Great progress has been made to increase our understanding of the molecular aspects that promote atherosclerosis initiation and progression, giving us the opportunity to develop new strategies for preventing and treating cardiovascular diseases.

This Special Issue of IJMS, ‘Atherosclerosis: From Molecular Basis to Therapy’, led by Prof. Massimiliano Ruscica, aims to focus on new insights, novel developments and discoveries, current challenges, and future perspectives in the field of atherosclerosis.

Prof. Massimiliano Ruscica
Guest Editor

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• atherosclerosis
• molecular basis
• cardiovascular disease
• artery disease
• vascular dementia