Autophagy and Immunoregulation in Human Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (29 April 2024) | Viewed by 1592
Special Issue Editors
2. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales (IQUIBICEN), Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas, Intendente Güiraldes 2160, Pabellón II, 4°piso, Ciudad Universitaria, Buenos Aires C1428EGA, Argentina
Interests: autophagy; immunoregulation; host immune response; immune evasion; signaling
Special Issue Information
Dear Colleagues,
Autophagy is an evolutionarily conserved catabolic pathway that mediates the lysosomal degradation of unwanted cytoplasmic structures and organelles, allowing eukaryotic cells to generate nutrients under starvation circumstances and maintain cellular homeostasis. Three types of autophagy have been described: chaperone-mediated autophagy, microautophagy, and macroautophagy, herein collectively referred to as autophagy. Importantly, autophagy participates in the immune response of the host against intracellular pathogens dealing with viruses or bacteria that gain access to the cytoplasm of the cell. Nevertheless, throughout evolution, the constant interaction between the autophagy pathway and pathogens allowed many pathogens to develop strategies to avoid autophagy, promoting their intracellular multiplication. Notably, autophagy constitutes an anti-inflammatory mechanism that protects against endomembrane damage triggered by several endogenous components or infectious agents, and precludes excessive inflammation. Moreover, selective autophagy modulates host immunity by turning over specific immunoregulators. In fact, the autophagy process can be modulated by diverse immunological mediators such as cytokines, lipid mediators or non-coding RNAs, among others. It has also been proposed that vaccines which may induce an autophagic response could be more successful in the prevention of several infections. Furthermore, it has been suggested that autophagy may be also considered an as adjuvant therapy in the treatment of some bacterial diseases. Therefore, improving our understanding of the connections between autophagy and host immunoregulation may have wide applications, given that the pathology accompanying several diseases involves some form of inflammation. This Special Issue welcomes the submission of original research articles and reviews on the topic “Autophagy and Immunoregulation in Human Diseases”, focused on understanding the immunoregulation of the autophagy process by the host immune system. We are interested in all aspects of in vitro and in vivo research. This Research Topic intends to provide an overview of the autophagy process and immunoregulators, focusing on the molecular strategies developed by pathogens to manipulate selective autophagy for their own benefit.
Dr. Veronica Edith Garcia
Dr. María Isabel Colombo
Guest Editors
Manuscript Submission Information
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Keywords
- autophagy
- immunoregulation
- pathogens
- host immune response
- immune evasion
- signaling
- non-coding RNAs
- lipid mediators
- cytokines
- host defense
