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New Insights into Liver Biology and Disease Pathogenesis: Shedding Light on Novel Diagnostic and Therapeutic Approaches

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 29 July 2024 | Viewed by 313

Special Issue Editor


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Guest Editor
Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
Interests: liver fibrosis; host-pathogen interactions; metabolic dysfunction associated steatotic liver disease (MASLD); schistosomiasis; viral hepatitis; biomarkers; drug targets; hedgehog signaling
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Special Issue Information

Dear Colleagues,

Despite advances in diagnosis, treatment, and prevention, diseases of the liver and biliary tract are still a significant cause of death worldwide. The recent 2023 Global Burden of Liver Diseases estimates that 4% of all deaths are attributed to liver diseases. Understanding basic liver molecular biology and disease pathogenesis can help us to identify novel biomarkers, improve diagnosis, and develop novel therapies and prevention strategies. In the past few years, single-cell transcriptomics, advanced culture systems, and CRISPR technology have enabled our community to start deciphering the molecular mechanisms underlying liver regeneration, repair, and carcinogenesis that could lead to clinical interventions to improve the quality of life of patients with liver diseases and reduce mortality.

This Special Issue aims to gather a collection of state-of-the-art and up-to-date articles covering recent advances in liver molecular biology and disease pathogenesis, including topics related to liver regeneration, repair, and carcinogenesis, the brain–gut–liver axis, novel therapeutic targets and interventions, diagnostic tools and morbidity biomarkers, host–pathogen interactions, and novel in vitro and in vivo models of liver diseases. Submission of basic and translational original research articles and reviews are welcome. Studies on liver diseases induced by infectious agents and on steatotic liver diseases are also encouraged.

Dr. Thiago Almeida Pereira
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • liver molecular biology
  • novel biomarkers
  • liver regeneration
  • liver repair
  • liver carcinogenesis
  • brain–gut–liver axis
  • novel therapeutic targets
  • molecular diagnostic tools
  • host–pathogen interactions
  • novel in vitro and in vivo models of liver diseases
 

Published Papers (1 paper)

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Review

13 pages, 1147 KiB  
Review
Current Evidence and Perspectives of Cluster of Differentiation 44 in the Liver’s Physiology and Pathology
by Jinsol Han, Chanbin Lee and Youngmi Jung
Int. J. Mol. Sci. 2024, 25(9), 4749; https://doi.org/10.3390/ijms25094749 - 26 Apr 2024
Viewed by 215
Abstract
Cluster of differentiation 44 (CD44), a multi-functional cell surface receptor, has several variants and is ubiquitously expressed in various cells and tissues. CD44 is well known for its function in cell adhesion and is also involved in diverse cellular responses, such as proliferation, [...] Read more.
Cluster of differentiation 44 (CD44), a multi-functional cell surface receptor, has several variants and is ubiquitously expressed in various cells and tissues. CD44 is well known for its function in cell adhesion and is also involved in diverse cellular responses, such as proliferation, migration, differentiation, and activation. To date, CD44 has been extensively studied in the field of cancer biology and has been proposed as a marker for cancer stem cells. Recently, growing evidence suggests that CD44 is also relevant in non-cancer diseases. In liver disease, it has been shown that CD44 expression is significantly elevated and associated with pathogenesis by impacting cellular responses, such as metabolism, proliferation, differentiation, and activation, in different cells. However, the mechanisms underlying CD44’s function in liver diseases other than liver cancer are still poorly understood. Hence, to help to expand our knowledge of the role of CD44 in liver disease and highlight the need for further research, this review provides evidence of CD44’s effects on liver physiology and its involvement in the pathogenesis of liver disease, excluding cancer. In addition, we discuss the potential role of CD44 as a key regulator of cell physiology. Full article
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