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Advances in Skin Cancer Pathology: From Pathogenesis to Precision Therapies

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 26 July 2024 | Viewed by 2380

Special Issue Editor


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Guest Editor
1. Pathophysiology Department, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Târgu Mures, 540139 Targu Mures, Romania
2. Pathology Department, Mures Clinical County Hospital, 540142 Targu Mures, Romania
Interests: dermatopathology; melanoma; tumor markers; immunohistochemistry; molecular pathology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Skin cancer is a pressing global health concern with increasing incidence rates, and this Special Issue aims to provide a platform for the dissemination of cutting-edge research and knowledge in this field. Our objective is to collect a diverse range of research articles, reviews, and original contributions that address various aspects of skin cancer, including its epidemiology, etiology, pathogenesis, diagnostic approaches, novel therapies, and prevention strategies.

We invite contributions from researchers, clinicians, scientists, and pathologists to submit their work on topics such as melanoma, non-melanoma skin cancers, risk factors, molecular mechanisms, therapeutic strategies, and emerging technologies. Our goal is to foster a multidisciplinary approach, promoting collaboration between experts in dermatology, oncology, genetics, molecular biology, and pathology.

Through this Special Issue, we aim to advance our knowledge of skin cancer, ultimately contributing to better diagnostic methods, treatment options, and preventive measures. We look forward to receiving high-quality research papers and reviews that will shed light on the intricacies of skin cancer and pave the way for improved patient care and outcomes.

Many thanks.

Prof. Dr. Ovidiu Simion Cotoi
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • skin cancer
  • melanoma
  • non-melanoma
  • immunotherapy
  • cutaneous malignancies
  • targeted therapy
  • early detection

Published Papers (1 paper)

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Research

18 pages, 7504 KiB  
Article
Pathophysiology, Histopathology, and Differential Diagnostics of Basal Cell Carcinoma and Cutaneous Squamous Cell Carcinoma—An Update from the Pathologist’s Point of View
by Iuliu Gabriel Cocuz, Maria Cătălina Popelea, Raluca Niculescu, Andrei Manea, Adrian-Horațiu Sabău, Andreea-Cătălina Tinca, Andreea Raluca Szoke, Corina Eugenia Budin, Adina Stoian, Silviu Horia Morariu, Titiana Cornelia Cotoi, Maria-Elena Cocuz and Ovidiu Simion Cotoi
Int. J. Mol. Sci. 2024, 25(4), 2220; https://doi.org/10.3390/ijms25042220 - 13 Feb 2024
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Abstract
Basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (cSCC) are the most frequently occurring non-melanocytic skin cancers. The objective of our study is to present the pathophysiology of BCC and cSCC and its direct relationship with the histopathological diagnostics and the differential [...] Read more.
Basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (cSCC) are the most frequently occurring non-melanocytic skin cancers. The objective of our study is to present the pathophysiology of BCC and cSCC and its direct relationship with the histopathological diagnostics and the differential diagnostics of these types of cancer, based on the morphological characteristics, immunohistochemical profile, and genetic alterations. The qualitative study was based on emphasizing the morphological characteristics and immunohistochemistry profiles of BCC and cSCC and the differential diagnostics based on the tissue samples from the Clinical Pathology Department of Mures Clinical County Hospital between 2020 and 2022. We analyzed the histopathological appearances and immunohistochemical profiles of BCC and cSCC in comparison with those of Bowen disease, keratoacanthoma, hyperkeratotic squamous papilloma, metatypical carcinoma, pilomatricoma, trichoblastoma, Merkel cell carcinoma, pleomorphic dermal sarcoma (PDS), and melanoma. Our study showed the importance of the correct histopathological diagnosis, which has a direct impact on the appropriate treatment and outcome for each patient. The study highlighted the histopathological and morphological characteristics of NMSCs and the precursor lesions in HE and the immunohistochemical profile for lesions that may make the differential diagnosis difficult to establish. Full article
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