Oxidative Stress and Inflammation in the Tissue Repair—Pathways and Biotechnologies

Dear Colleagues,

Oxinflammation is an important process that is activated during the recovery of tissue lesions. Mitochondria play a fundamental role because, during the transport of the electrons in the inner mitochondria membrane, the production of free radicals, reactive oxygen species (ROS), and reactive nitrogen species (RNS), such as superoxide (O₂^•−), nitric oxide (NO^•), nitrogen dioxide (NO₂^•), hydroxyl radical (OH^•), hydroperoxyl radical (HO₂^•), and peroxyl (ROO^•), is common.  The relationship between oxidative stress and inflammation during tissue repair is linked to the activation of neutrophils, which are macrophages responsible for the release of interferon-γ (IFN-δ) and interleukins (IL) which will then promote the activation of NF-kB pathways and IL-12, TNF-α, IL-6, and IL-8 release. These are essential for resolving inflammatory progression. Currently, there is an increasing interest in the biotechnological and pharmacological development of more effective approaches to the treatment of different types of injuries in target organs. In regenerative medicine, natural products derived from plants, animals, minerals, and microorganisms have been considered rich sources of bioactive molecules, with potential relevance and applicability in direct or complementary strategies focused on tissue repair. This Special Issue aims to create an interdisciplinary platform involving morphological, physiological, biochemical, molecular, pathological, and biotechnological issues to discuss the identification, relevance, and applicability of natural products in the repair of tissue and organ injuries. We welcome primary research articles (in silico, in vitro, and in vivo) and secondary studies (critical integrative and systematic reviews) illustrating and stimulating the continuing effort to understand the effect of biotechnology compounds in the repair of the different morphological and/or functional disorders of target organs caused by physical, chemical, biological, and/or genetic processes.

Dr. Reggiani Vilela Goncalves
Dr. Rômulo Dias Novaes
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• oxidative stress
• inflammasome
• cytokines
• angiogenesis
• remodeling
• molecular pathways
• apoptotic alterations
• diabetes
• tissue repair