The Inflammatory and Immune Response to Helicobacter pylori Infection
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Microbiology".
Deadline for manuscript submissions: 20 June 2024 | Viewed by 943
Special Issue Editors
Interests: GI diseases; comorbidity; gastrointestinal microbiota; Helicobacter pylori; microbial metabolism
Special Issue Information
Dear Colleagues,
Helicobacter pylori is generally regarded as a human pathogen and a carcinogen, responsible for about 15% of the total cancer burden globally and up to 90% of all gastric cancer cases. H. pylori is etiologically related to gastric and duodenal ulcers and mucosa-associated lymphoid tissue lymphoma.
Unlike other pathogenic/opportunistic bacteria/pathobionts, H. pylori colonization of infants is facilitated by T helper type 2 immunity and leads to the development of immune tolerance. Most likely, the co-evolution of H. pylori and the human host over millennia has led to the fact that this bacterium is considered a commensal symbiont, not only a pathogen, by the host’s immune system, allowing it to evade the immune response.
The induction of the innate immune response by H. pylori plays a critical role in the outcome of the infection. However, since sequelae of infection occur in only 20% of infected patients, and malignancies occur in <3%, it is clear that other factors and mechanisms regulate the localized non-specific response, including the gastrointestinal microbiota and genetic factors.
Thus, the pathophysiology of H. pylori infection and its clinical outcome should be viewed as a complex interaction between the host, the bacterium, and the gastrointestinal microbiota. This interaction is influenced by the environment and modulated by a variety of largely as yet unidentified factors.
Thus, there is a clear need for studies describing the factors that induce and regulate the immune response during H. pylori infection, as well as for innovative approaches to H. pylori infection management.
This Special Issue will focus on the latest advances in understanding the induction and regulation of the inflammatory and immune response to H. pylori infection, as well as potential tools for its modulation and innovative eradication strategies, including but not limited to novel antibacterials, probiotics, postbiotic metabolites, phytochemicals, and bacteriophages.
Prof. Dr. Leonid B. Lazebnik
Dr. Stanislav Sitkin
Guest Editors
Manuscript Submission Information
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Keywords
- adhesion
- antibiotics resistance
- bacteriophages
- chronic inflammation
- dysbiosis
- eradication
- fucosylated glycan
- gastric cancer
- gastric microbiota
- gut microbiota
- Helicobacter pylori
- H. pylori-associated gastritis
- H. pylori differ stamms
- host immune response
- inflammasome
- inflammatory response
- innate immunity
- Lewis system antigens
- matrix metalloproteinases
- microbial interaction
- microbial metabolites
- microRNA
- molecular mimicry
- non-coding RNA
- oxidative stress
- pathogen-associated molecular patterns
- pattern recognition receptors
- phytochemicals
- postbiotics
- probiotics
- synthetic peptides
- vaccine
- virulence factors
