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Updates on Synthetic and Natural Antioxidants
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Updates on Synthetic and Natural Antioxidants

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 30 August 2024 | Viewed by 396

Special Issue Editors

Prof. Dr. Izabela Sadowska-Bartosz

E-Mail Website
Guest Editor
Laboratory of Analytical Biochemistry, Institute of Food Technology and Nutrition, College of Natural Sciences, University of Rzeszow, Rzeszow, Poland
Interests: biochemistry of oxidative stress; antioxidants; enzymology; neurobiology; biogerontology
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Grzegorz Bartosz

E-Mail Website
Guest Editor
Institute of Food Technology and Nutrition, College of Natural Sciences, University of Rzeszow, Rzeszow, Poland
Interests: free radicals; reactive oxygen species; antioxidants; membranes
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Our knowledge in the field of antioxidants is rapidly expanding due to the extensive research on both natural and synthetic antioxidants. New natural antioxidants are being discovered, and new semi-synthetic and synthetic antioxidants are being produced. Studies on the mechanisms of action of antioxidants, interactions between antioxidants, and the beneficial and adverse effects of antioxidant compounds are being performed.

As a Guest Editor of the Special Issue “Updates on Synthetic and Natural Antioxidants” of IJMS, I invite you to contribute articles presenting the latest research addressing the occurrence, chemistry, biochemistry, cellular effects, and organismal effects of antioxidants and plant stress mechanisms at the biochemical, physiological, molecular, and genetic levels. Further, contributions describing new methods, protocols, and devices for studying antioxidants are welcome.

Prof. Dr. Izabela Sadowska-Bartosz
Prof. Dr. Grzegorz Bartosz
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antioxidants
  • synthetic
  • natural compounds

Published Papers (1 paper)

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Research

16 pages, 4424 KiB  
Article
Effect of Garlic Extract on the Erythrocyte as a Simple Model Cell
by Paulina Furdak, Grzegorz Bartosz, Ireneusz Stefaniuk, Bogumił Cieniek, Edyta Bieszczad-Bedrejczuk, Mirosław Soszyński and Izabela Sadowska-Bartosz
Int. J. Mol. Sci. 2024, 25(10), 5115; https://doi.org/10.3390/ijms25105115 - 8 May 2024
Viewed by 131
Abstract
Garlic is known to have diverse effects on mammalian cells, being cytotoxic, especially to cancer cells, but also protect against oxidative stress. Mammalian erythrocyte is a simple cell devoid of intracellular organelles, protein synthesis ability, and most signaling pathways. Therefore, examination of the [...] Read more.
Garlic is known to have diverse effects on mammalian cells, being cytotoxic, especially to cancer cells, but also protect against oxidative stress. Mammalian erythrocyte is a simple cell devoid of intracellular organelles, protein synthesis ability, and most signaling pathways. Therefore, examination of the effects of garlic on erythrocytes allows for revealing primary events in the cellular action of garlic extract. In this study, human erythrocytes or erythrocyte membranes were exposed to garlic extract at various dilutions. Hemoglobin oxidation to methemoglobin, increased binding of hemoglobin to the membrane, and formation of Heinz bodies were observed. Garlic extract depleted acid-soluble thiols, especially glutathione, and induced a prooxidative shift in the cellular glutathione redox potential. The extract increased the osmotic fragility of erythrocytes, induced hemolysis, and inhibited hemolysis in isotonic ammonium chloride, indicative of decreased membrane permeability for Cl− and increased the membrane fluidity. Fluorescent probes indicated an increased level of reactive oxygen species and induction of lipid peroxidation, but these results should be interpreted with care since the extract alone induced oxidation of the probes (dichlorodihydrofluorescein diacetate and BODIPY C11). These results demonstrate that garlic extract induces oxidative changes in the erythrocyte, first of all, thiol and hemoglobin oxidation. Full article
(This article belongs to the Special Issue Updates on Synthetic and Natural Antioxidants)
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