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Latest Review Papers in Molecular Endocrinology and Metabolism 2023
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Latest Review Papers in Molecular Endocrinology and Metabolism 2023

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".

Deadline for manuscript submissions: closed (30 June 2023) | Viewed by 3061

Special Issue Editors

Prof. Dr. Micheline Misrahi

E-Mail Website
Guest Editor
Unité de Génétique Moléculaire des Maladies Métaboliques et de la Reproduction, APHP Hôpitaux Universitaires Paris-Saclay, Hôpital Bicêtre, Faculté de Médecine Paris Saclay, 94275 Le Kremlin-Bicêtre, France
Interests: molecular and cellular mechanisms in reproductive endocrinology; nuclear receptors; membrane receptors; gonadotropins and their receptors; thyrotropin receptor; reproductive genetics; genetics of male and female infertility; primary ovarian insufficiency; disorders of puberty; genetic diseases of GPCR
Special Issues, Collections and Topics in MDPI journals
Dr. Dumitru Constantin-Teodosiu

E-Mail Website
Guest Editor
Division of Physiology, Pharmacology and Neuroscience, School of Life Sciences, Queen’s Medical Centre, University of Nottingham Medical School, Nottingham NG7 2UH, UK
Interests: type 2 diabetes; muscle insulin resistance; sepsis; inflammation; energy metabolism; ageing; inactivity
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue aims to collect high-quality review papers in all fields of molecular endocrinology and metabolism. We encourage researchers from related fields to contribute review papers that highlight the latest developments in molecular endocrinology and metabolism, or to invite relevant experts and colleagues to do so. Full length comprehensive reviews will be preferred.

Prof. Dr. Micheline Misrahi
Dr. Dumitru Constantin-Teodosiu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (2 papers)

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Review

14 pages, 753 KiB  
Review
Interplay between Vitamin D and Sphingolipids in Cardiometabolic Diseases
by Simona Fenizia, Melania Gaggini and Cristina Vassalle
Int. J. Mol. Sci. 2023, 24(23), 17123; https://doi.org/10.3390/ijms242317123 - 4 Dec 2023
Cited by 1 | Viewed by 847
Abstract
Sphingolipids (SLs) are structural, bioactive molecules with several key cellular roles, whereas 1,25-dihydroxyvitamin D (1,25(OH)D), the active form of vitamin D, is considered the major regulator of calcium homeostasis, although it also exerts other extraskeletal effects. Many studies reported the physiological connection between [...] Read more.
Sphingolipids (SLs) are structural, bioactive molecules with several key cellular roles, whereas 1,25-dihydroxyvitamin D (1,25(OH)D), the active form of vitamin D, is considered the major regulator of calcium homeostasis, although it also exerts other extraskeletal effects. Many studies reported the physiological connection between vitamin D and SLs, highlighting not only the effects of vitamin D on SL metabolism and signaling but also the influence of SLs on vitamin D levels and function, thus strongly suggesting a crosstalk between these molecules. After a brief description of 1,25(OH)D and SL metabolism, this review aims to discuss the preclinical and clinical evidence on the crosstalk between SLs and 1,25(OH)D, with a special focus on cardiometabolic diseases. Full article
(This article belongs to the Special Issue Latest Review Papers in Molecular Endocrinology and Metabolism 2023)
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15 pages, 1755 KiB  
Review
The Dual Role of Oxidants in Male (In)fertility: Every ROSe Has a Thorn
by Antonio Mancini, Alessandro Oliva, Edoardo Vergani, Roberto Festa and Andrea Silvestrini
Int. J. Mol. Sci. 2023, 24(5), 4994; https://doi.org/10.3390/ijms24054994 - 5 Mar 2023
Cited by 5 | Viewed by 1913
Abstract
The role of oxidative stress (OS) in male infertility as a primary etiology and/or concomitant cause in other situations, such as inflammation, varicocele and gonadotoxin effects, is well documented. While reactive oxygen species (ROS) are implicated in many important roles, from spermatogenesis to [...] Read more.
The role of oxidative stress (OS) in male infertility as a primary etiology and/or concomitant cause in other situations, such as inflammation, varicocele and gonadotoxin effects, is well documented. While reactive oxygen species (ROS) are implicated in many important roles, from spermatogenesis to fertilization, epigenetic mechanisms which are transmissible to offspring have also recently been described. The present review is focused on the dual aspects of ROS, which are regulated by a delicate equilibrium with antioxidants due to the special frailty of spermatozoa, in continuum from physiological condition to OS. When the ROS production is excessive, OS ensues and is amplified by a chain of events leading to damage of lipids, proteins and DNA, ultimately causing infertility and/or precocious pregnancy termination. After a description of positive ROS actions and of vulnerability of spermatozoa due to specific maturative and structural characteristics, we linger on the total antioxidant capacity (TAC) of seminal plasma, which is a measure of non-enzymatic non-proteic antioxidants, due to its importance as a biomarker of the redox status of semen; the therapeutic implications of these mechanism play a key role in the personalized approach to male infertility. Full article
(This article belongs to the Special Issue Latest Review Papers in Molecular Endocrinology and Metabolism 2023)
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