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Recent Advances in Photobiomodulation Therapy (PBMT)

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A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 30 June 2024 | Viewed by 3413

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Special Issue Editors

Dr. Min-Young Lee

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Guest Editor

Department of Otorhinolaryngology, School of Medicine, Dankook University, Cheonan, Republic of Korea
Interests: hearing research; vestibular science; photobiomodulation; regeneration; stem cell

Dr. Jin-Chul Ahn

E-Mail Website
Guest Editor

Department of Biomedical Science, College of Medicine, Dankook University, Cheonan 31116, Republic of Korea
Interests: low level laser therapy; phototherapy; light emitting diodes; sulforaphane; apoptosis; isothiocyanic acid derivative

Special Issue Information

Dear Colleagues,

Photobiomodulation (PBMT), known as low-level light therapy, is a non-invasive technique that is used in the visible and near-infrared spectrum to stimulate and promote cellular function.

The light energy used in PBMT is absorbed by cells, triggering a series of biochemical reactions that ultimately improve cell function and tissue healing. Because of this, it can be applied to various tissues in the body, including skin, muscles, joints and organs to reduce inflammation, promote tissue repair and reduce pain; therefore, it is used in a variety of medical applications. Research is being actively conducted on PBMT to further understand its potential for treating various incurable diseases; research has shown that PBMT has promising therapeutic effects in combination therapy.

The purpose of this Special Issue is to report on recent advances in PBMT therapy in various fields. These include gene and stem cell therapy, and the differentiation of neural or non-neural target cells from organoids, but other studies can also be comprehensively reported.

We welcome a wide variety of studies confirming the effect of PBMT.

Dr. Min-Young Lee
Dr. Jin-Chul Ahn
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

photobiomodulation (PBMT)
low-level light therapy
biostimulation
gene therapy
stem cell therapy
neural or non-neural differentiation
differentiation from organoids
intractable disease

Published Papers (3 papers)

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Research

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12 pages, 2083 KiB

Open AccessArticle

The Anti-Inflammatory Effect of Multi-Wavelength Light-Emitting Diode Irradiation Attenuates Dry Eye Symptoms in a Scopolamine-Induced Mouse Model of Dry Eye

by Hyeyoon Goo, Yea-Jin Lee, Sangkeun Lee and Namgue Hong

Int. J. Mol. Sci. 2023, 24(24), 17493; https://doi.org/10.3390/ijms242417493 - 14 Dec 2023

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Abstract

Dry eye disease is a common condition in patients of all ages, causing discomfort and potential visual problems. Current treatments, including artificial tears and anti-inflammatory drugs, have certain limitations, encouraging research into alternative therapies. We investigated the therapeutic potential of multi-wavelength light-emitting diode (LED) irradiation of mice with dry eye. First, we showed that multi-wavelength LED irradiation was non-toxic to human corneal epithelial cells and improved cell viability. We then used a scopolamine-induced mouse model of dry eye to assess the effects of multi-wavelength LED irradiation on various clinical parameters. This treatment increased the tear volume and reduced corneal irregularity, thus improving dry eye. Histological analysis revealed that multi-wavelength LED irradiation protected against corneal epithelial damage and the associated reduction in epithelial thickness and would thus improve the corneal health of dry eye patients. Multi-wavelength LED irradiation significantly reduced the corneal levels of pro-inflammatory cytokines IL-6, IL-1β, and TNF-α; the treatment was thus anti-inflammatory. Our results suggest that multi-wavelength LED irradiation may serve as a safe and effective treatment for dry eye, alleviating symptoms, reducing inflammation, and promoting corneal health. Full article

(This article belongs to the Special Issue Recent Advances in Photobiomodulation Therapy (PBMT))

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15 pages, 5196 KiB

Open AccessArticle

Multi-Wavelength Photobiomodulation Ameliorates Sodium Iodate-Induced Age-Related Macular Degeneration in Rats

by Hyeyoon Goo, Min Young Lee, Yea-Jin Lee, Sangkeun Lee, Jin-Chul Ahn and Namgue Hong

Int. J. Mol. Sci. 2023, 24(24), 17394; https://doi.org/10.3390/ijms242417394 - 12 Dec 2023

Cited by 1 | Viewed by 879

Abstract

Age-related macular degeneration (AMD) is a global health challenge. AMD causes visual impairment and blindness, particularly in older individuals. This multifaceted disease progresses through various stages, from asymptomatic dry to advanced wet AMD, driven by various factors including inflammation and oxidative stress. Current treatments are effective mainly for wet AMD; the therapeutic options for dry AMD are limited. Photobiomodulation (PBM) using low-energy light in the red-to-near-infrared range is a promising treatment for retinal diseases. This study investigated the effects of multi-wavelength PBM (680, 780, and 830 nm) on sodium iodate-induced oxidatively damaged retinal tissue. In an in vivo rat model of AMD induced by sodium iodate, multi-wavelength PBM effectively protected the retinal layers, reduced retinal apoptosis, and prevented rod bipolar cell depletion. Furthermore, PBM inhibited photoreceptor degeneration and reduced retinal pigment epithelium toxicity. These results suggest that multi-wavelength PBM may be a useful therapeutic strategy for AMD, mitigating oxidative stress, preserving retinal integrity, and preventing apoptosis. Full article

(This article belongs to the Special Issue Recent Advances in Photobiomodulation Therapy (PBMT))

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Review

Jump to: Research

16 pages, 1117 KiB

Open AccessReview

Photobiomodulation of Neurogenesis through the Enhancement of Stem Cell and Neural Progenitor Differentiation in the Central and Peripheral Nervous Systems

by So-Young Chang and Min Young Lee

Int. J. Mol. Sci. 2023, 24(20), 15427; https://doi.org/10.3390/ijms242015427 - 21 Oct 2023

Cited by 1 | Viewed by 1294

Abstract

Photobiomodulation (PBM) is the regulation of biological processes using light energy from sources such as lasers or light-emitting diodes. Components of the nervous system, such as the brain and peripheral nerves, are important candidate PBM targets due to the lack of therapeutic modalities for the complete cure of neurological diseases. PBM can be applied either to regenerate damaged organs or to prevent or reduce damage caused by disease. Although recent findings have suggested that neural cells can be regenerated, which contradicts our previous understanding, neural structures are still thought to have weaker regenerative capacity than other systems. Therefore, enhancing the regenerative capacity of the nervous system would aid the future development of therapeutics for neural degeneration. PBM has been shown to enhance cell differentiation from stem or progenitor cells to near-target or target cells. In this review, we have reviewed research on the effects of PBM on neurogenesis in the central nervous system (e.g., animal brains) and the peripheral nervous system (e.g., peripheral sensory neural structures) and sought its potential as a therapeutic tool for intractable neural degenerative disorders. Full article

(This article belongs to the Special Issue Recent Advances in Photobiomodulation Therapy (PBMT))

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