New Advances in Molecular Research of Coronavirus
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".
Deadline for manuscript submissions: 20 March 2025 | Viewed by 9862
Special Issue Editors
Interests: COVID-19; signaling; endothelial cells
2. Laboratory of Cellular and Molecular Pathology of Cardiovascular System, Avtsyn Research Institute of Human Morphology of Federal State Budgetary Scientific Institution “Petrovsky National Research Center of Surgery”, 117418 Moscow, Russia
3. Department of Biology and General Genetics, I.M. Sechenov First Moscow State Medical University (Sechenov University), 105043 Moscow, Russia
Interests: atherosclerosis; mitophagy; atherogenicity; atherosclerosis; autoantibodies; inflammation; innate immunity; amyloid
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Special Issue Information
Dear Colleagues,
More than two years have passed since the start of the COVID-19 pandemic. During this time, thanks to the creation of effective vaccines, the development of new treatment protocols, the emergence of mass immunity, and the evolution of the virus towards less dangerous variants, the severity of coronavirus infection and mortality have decreased significantly; however, as a result of the mutations of SARS-CoV-2, the effectiveness of existing vaccines is reduced and the use of drugs that affect links of the pathological process, such as the interaction of the viral part with receptors and its reproduction in cells, is becoming more and more relevant. In this regard it is necessary to conduct research on the creation of new targeted drugs that inactivate SARS-CoV-2, as well as on the use of already-known drugs (drug repurposing) that can suppress the transport of viral particles into cells and neutralize the proinflammatory effect of coronavirus on the body. Despite progress in understanding the pathogenesis of COVID-19, it remains unclear as to what determines a predisposition to severe COVID-19. Further work is required to identify therapy indicators and genetic factors that can serve as prognostic signs of the development of a severe form of this disease. The canonical receptor for SARS-CoV-2 is ACE2; however, new data are emerging regarding the binding of SARS-CoV-2 onto the plasma membrane and the mechanisms of the penetration of viral particles into cells. The role of alternative SARS-CoV-2 receptors in the damage of organs and tissues of the body has not been fully elucidated. After the end of the peak phase of the pandemic, the focus in the fight against COVID-19 is shifting towards overcoming the consequences of this disease, which include musculoskeletal, digestive, and neurological symptoms, pediatric inflammatory multisystem syndrome, and disorders of the blood coagulation system as well as microcirculation. Therefore, it is important to discuss the pathogenetic mechanisms of post-COVID syndrome.
The purpose of this Special Issue is to discuss the issues raised, summarize the accumulated information, and present new data on the pathogenesis of COVID-19.
Prof. Dr. Pavel Avdonin
Dr. Evgeny E. Bezsonov
Guest Editors
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Keywords
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COVID-19
- pathogenesis
- SARS-CoV-2 receptors
- drug repurposing
- drug targets and potential treatments
- prevention of post-COVID syndrome
- thrombosis
- kidney disease
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