Research Progress of Tumor Endothelial Cells
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: closed (30 April 2024) | Viewed by 1165
Special Issue Editor
Special Issue Information
Dear Colleagues,
The complex interplay of tumor cells and stromal cells of the tumor microenvironment significantly impacts abnormal proliferation, invasion, metastasis, and other hallmarks of cancer. Single-cell RNA sequencing analyses have provided fascinating new insights into the cellular composition of the tumor microenvironment in recent years.
Tumor endothelial cells (TECs), which differ significantly from normal endothelial cells at the genetic, molecular, metabolic, and functional levels, can support tumor progression and metastasis, for example, by promoting angiogenesis or modulating the anticancer immune response. Due to their important role in the tumor microenvironment, TECs have been identified as promising targets for cancer therapy. In addition to anti-angiogenic treatments, immunomodulatory approaches are increasingly focusing on TECs. However, in addition to new insights into the origin and characteristics of TECs, we have recently learned a lot about the inter- and intratumoral heterogeneity of TECs, which may influence the efficacy of cancer therapies.
This Special Issue of the International Journal of Molecular Sciences, entitled “Research Progress of Tumor Endothelial Cells”, focuses on a better understanding of the molecular, functional, and metabolic characteristics of TECs, their role in the tumor microenvironment and novel targets for cancer therapy. We welcome both original research articles and up-to-date review papers from fundamental, clinical, and translational research.
Prof. Dr. Matthias Rath
Guest Editor
Manuscript Submission Information
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Keywords
- tumorigenesis
- cancer
- metastasis
- endothelial cells (ECs)
- tumor cells
- tumor microenvironment
- metabolism
- proliferation
- invasion
- vascular
- microvascular
- tumor angiogenesis
- sprouting
